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• W2021984977 abstract "Abstract Heterologous prime‐boost vaccination employing DNA‐vaccinia virus (VACV) modality using the Leishmania homologue of receptors for activated C kinase (LACK) (p36) antigen has been shown to elicit protective immunity against both murine cutaneous and visceral leishmaniasis. However, DNA priming is known to have limited efficacy; therefore in the current study the effect of NKT cell activation using α‐galactosyl‐ceramide (αGalCer) during intradermal DNAp36 priming was examined. Vaccinated mice receiving αGalCer + DNAp36 followed by a boost with VVp36 appeared to be resolving their lesions and had at ten‐ to 20‐fold higher reductions in parasite burdens. NKT cell activation during αGalCer + DNAp36 priming resulted in higher numbers of antigen‐reactive effector CD4 + and CD8 + T cells producing granzyme and IFN‐γ, with lower levels of IL‐10. Although immunodepletion studies indicate that both CD4 and CD8 T cells provide protection in the vaccinated mice, the contribution of CD4 + T cells was significantly increased in mice primed with DNAp36 together with αGalCer. Notably 5 months after boosting, mice vaccinated with DNAp36 + αGalCer continued to show sustained and heightened T cell immune responses. Thus, heterologous prime‐boost vaccination using αGalCer during priming is highly protective against murine cutaneous leishmaniasis, resulting in the heightened activation and development of CD4 and CD8 T cells (effector and memory T cells)." @default.
• W2021984977 created "2016-06-24" @default.
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• W2021984977 date "2008-02-19" @default.
• W2021984977 modified "2023-10-17" @default.
• W2021984977 title "Intradermal NKT cell activation during DNA priming in heterologous prime‐boost vaccination enhances T cell responses and protection against <i>Leishmania</i>" @default.
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• W2021984977 doi "https://doi.org/10.1002/eji.200737660" @default.
• W2021984977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3448375" @default.

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