Matches in SemOpenAlex for { <https://semopenalex.org/work/W2021998260> ?p ?o ?g. }
- W2021998260 endingPage "102" @default.
- W2021998260 startingPage "96" @default.
- W2021998260 abstract "Citrate synthase (CS) is an enzyme of the Krebs cycle that plays a key role in mitochondrial metabolism. The aim of this study was to investigate the mechanisms underlying low activity of citrate synthase (CS) in A/J mice compared with other inbred strains of mice. Enzyme activity, protein content, and mRNA levels of CS were studied in the quadriceps muscles of A/J, BALB/cByJ, C57BL/6J, C3H/HeJ, DBA/2J, and PWD/PhJ strains of mice. Cytochrome c protein content was also measured. The results of the study indicate that A/J mice have a 50-65% reduction in CS activity compared with other strains despite similar levels of Cs mRNA and lack of differences in CS and cytochrome c protein content. CS from A/J mice also showed lower Michaelis constant (K(m)) for both acetyl CoA and oxaloacetate compared with the other strains of mice. In silico analysis of the genomic sequence identified a nonsynonymous single nucleotide polymorphism (SNP) (rs29358506, H55N) in Cs gene occurring near the site of the protein interacting with acetyl CoA. Allelic variants of the polymorphism segregated with the catalytic properties of CS enzyme among the strains. In summary, H55N polymorphism in Cs could be the underlying cause of low CS activity and its high affinity for substrates in A/J mice compared with other strains. This SNP might also play a role in resistance to obesity of A/J mice." @default.
- W2021998260 created "2016-06-24" @default.
- W2021998260 creator A5025847134 @default.
- W2021998260 creator A5027590398 @default.
- W2021998260 creator A5048773182 @default.
- W2021998260 creator A5050542171 @default.
- W2021998260 creator A5056984214 @default.
- W2021998260 creator A5057541782 @default.
- W2021998260 creator A5057899222 @default.
- W2021998260 creator A5084801323 @default.
- W2021998260 date "2010-10-01" @default.
- W2021998260 modified "2023-10-16" @default.
- W2021998260 title "H55N polymorphism as a likely cause of variation in citrate synthase activity of mouse skeletal muscle" @default.
- W2021998260 cites W1485223239 @default.
- W2021998260 cites W170853393 @default.
- W2021998260 cites W1968024017 @default.
- W2021998260 cites W1971836750 @default.
- W2021998260 cites W1995004764 @default.
- W2021998260 cites W2000301075 @default.
- W2021998260 cites W2004655740 @default.
- W2021998260 cites W2006937646 @default.
- W2021998260 cites W2008341411 @default.
- W2021998260 cites W2029665038 @default.
- W2021998260 cites W2035546417 @default.
- W2021998260 cites W2040045236 @default.
- W2021998260 cites W2057945210 @default.
- W2021998260 cites W2060450389 @default.
- W2021998260 cites W2063590495 @default.
- W2021998260 cites W2077412323 @default.
- W2021998260 cites W2092537435 @default.
- W2021998260 cites W2099682589 @default.
- W2021998260 cites W2102126633 @default.
- W2021998260 cites W2109372707 @default.
- W2021998260 cites W2115487899 @default.
- W2021998260 cites W2115928938 @default.
- W2021998260 cites W2121876585 @default.
- W2021998260 cites W2134107373 @default.
- W2021998260 cites W2134705056 @default.
- W2021998260 cites W2134843156 @default.
- W2021998260 cites W2140140747 @default.
- W2021998260 cites W2140231697 @default.
- W2021998260 cites W2145277191 @default.
- W2021998260 cites W2154713757 @default.
- W2021998260 cites W2160945753 @default.
- W2021998260 cites W2166198172 @default.
- W2021998260 cites W2167775693 @default.
- W2021998260 cites W2168456856 @default.
- W2021998260 cites W2174978286 @default.
- W2021998260 cites W2187321354 @default.
- W2021998260 cites W4245271255 @default.
- W2021998260 doi "https://doi.org/10.1152/physiolgenomics.00066.2010" @default.
- W2021998260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20716647" @default.
- W2021998260 hasPublicationYear "2010" @default.
- W2021998260 type Work @default.
- W2021998260 sameAs 2021998260 @default.
- W2021998260 citedByCount "22" @default.
- W2021998260 countsByYear W20219982602012 @default.
- W2021998260 countsByYear W20219982602013 @default.
- W2021998260 countsByYear W20219982602015 @default.
- W2021998260 countsByYear W20219982602017 @default.
- W2021998260 countsByYear W20219982602019 @default.
- W2021998260 countsByYear W20219982602020 @default.
- W2021998260 countsByYear W20219982602021 @default.
- W2021998260 countsByYear W20219982602022 @default.
- W2021998260 countsByYear W20219982602023 @default.
- W2021998260 crossrefType "journal-article" @default.
- W2021998260 hasAuthorship W2021998260A5025847134 @default.
- W2021998260 hasAuthorship W2021998260A5027590398 @default.
- W2021998260 hasAuthorship W2021998260A5048773182 @default.
- W2021998260 hasAuthorship W2021998260A5050542171 @default.
- W2021998260 hasAuthorship W2021998260A5056984214 @default.
- W2021998260 hasAuthorship W2021998260A5057541782 @default.
- W2021998260 hasAuthorship W2021998260A5057899222 @default.
- W2021998260 hasAuthorship W2021998260A5084801323 @default.
- W2021998260 hasConcept C104317684 @default.
- W2021998260 hasConcept C111133373 @default.
- W2021998260 hasConcept C112243037 @default.
- W2021998260 hasConcept C119795356 @default.
- W2021998260 hasConcept C135763542 @default.
- W2021998260 hasConcept C141231307 @default.
- W2021998260 hasConcept C149904235 @default.
- W2021998260 hasConcept C153209595 @default.
- W2021998260 hasConcept C153911025 @default.
- W2021998260 hasConcept C180754005 @default.
- W2021998260 hasConcept C181199279 @default.
- W2021998260 hasConcept C200886947 @default.
- W2021998260 hasConcept C54355233 @default.
- W2021998260 hasConcept C55493867 @default.
- W2021998260 hasConcept C86803240 @default.
- W2021998260 hasConceptScore W2021998260C104317684 @default.
- W2021998260 hasConceptScore W2021998260C111133373 @default.
- W2021998260 hasConceptScore W2021998260C112243037 @default.
- W2021998260 hasConceptScore W2021998260C119795356 @default.
- W2021998260 hasConceptScore W2021998260C135763542 @default.
- W2021998260 hasConceptScore W2021998260C141231307 @default.
- W2021998260 hasConceptScore W2021998260C149904235 @default.
- W2021998260 hasConceptScore W2021998260C153209595 @default.
- W2021998260 hasConceptScore W2021998260C153911025 @default.