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- W2022000332 abstract "We identified two methionine aminopeptidases of Cryptosporidium parvum (CpMetAP1 and CpMetAP2) and characterized the biochemical properties of the recombinant enzymes. CpMetAP1 and CpMetAP2 belong to the type I and type II MetAP subfamilies, respectively. Both CpMetAPs have typical amino acid residues essential for metal binding and substrate binding sites, which are conserved in the MetAP family. Bacterially expressed recombinant CpMetAP1 and CpMetAP2 showed similar biochemical properties including a broad optimal pH range (pH 7.5–8.5) with maximum activity at pH 8.0. The two enzymes were stable under neutral and alkaline pHs but were relatively unstable under acidic conditions. The activities of CpMetAP1 and CpMetAP2 increased highly in the presence of Mn2+ and Co2+. CpMetAP1 and CpMetAP2 were effectively inhibited by the metal chelators, EDTA and 1,10-phenanthroline, and were partially inhibited by the aminopeptidase inhibitors, amastatin and bestatin. Fumagillin also showed an inhibitory effect on both CpMetAPs." @default.
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- W2022000332 date "2012-12-01" @default.
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- W2022000332 title "Characterization of the biochemical properties of two methionine aminopeptidases of Cryptosporidium parvum" @default.
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- W2022000332 doi "https://doi.org/10.1016/j.parint.2012.05.008" @default.
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