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• W2022000769 endingPage "1016" @default.
• W2022000769 startingPage "1009" @default.
• W2022000769 abstract "Angiotensin (Ang II) activates neuronal AT(1) receptors located in the hypothalamus and the brainstem and stimulates noradrenergic neurons that are involved in the control of blood pressure and fluid intake. In this study we used complementary DNA microarrays for high throughput gene expression profiling to reveal unique genes that are linked to the neuromodulatory actions of Ang II in neuronal cultures from newborn rat hypothalamus and brainstem. Of several genes that were regulated, we focused on calmodulin and synapsin I. Ang II (100 nM; 1-24 h) elicited respective increases and decreases in the levels of calmodulin and synapsin I messenger RNAs, effects mediated by AT(1) receptors. This was associated with similar changes in calmodulin and synapsin protein expression. The actions of Ang II on calmodulin expression involve an intracellular pathway that includes activation of phospholipase C, increased intracellular calcium, and stimulation of protein kinase C. Taken together with studies that link calmodulin and synapsin I to axonal transport and exocytotic processes, the data suggest that Ang II regulates these two proteins via a Ca(2+)-dependent pathway, and that this may contribute to longer term or slower neuromodulatory actions of this peptide." @default.
• W2022000769 created "2016-06-24" @default.
• W2022000769 creator A5004651591 @default.
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• W2022000769 date "2001-03-01" @default.
• W2022000769 modified "2023-10-18" @default.
• W2022000769 title "Gene Expression Profiling of Rat Brain Neurons Reveals Angiotensin II-Induced Regulation of Calmodulin and Synapsin I: Possible Role in Neuromodulation*" @default.
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• W2022000769 doi "https://doi.org/10.1210/endo.142.3.8016" @default.
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