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- W2022003608 abstract "In previous studies radiation-induced osteosarcoma transplanted onto nude rats has been shown to have an extraordinary similarity to human osteosarcoma. In this report the effects of a standard chemotherapeutic regimen on this experimental bone tumor are described. Examination of the histology and of the water content of the tumor confirmed that a high-dose cyclophosphamide monotherapy can cause severe necrosis in the tumor and its seeded lung metastases. A significant decrease in tumor volume of 50% (p ≤ 0.01) was provoked and increased the mean survival rate of the treated rats (untreated rats: mean = 39.3 days) significantly to 53.6 days after transplantation of tumor fragments (p ≤ 0.01)." @default.
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- W2022003608 date "1992-01-01" @default.
- W2022003608 modified "2023-09-25" @default.
- W2022003608 title "Experimental Animal Model for the Evaluation of Chemotherapeutical Effects on Osteosarcoma" @default.
- W2022003608 doi "https://doi.org/10.1159/000239008" @default.
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