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- W2022003992 abstract "An electron microscopic, morphometric analysis of isolated rat hepatocytes revealed a 70% decrease in the early forms of autophagic vacuoles after administration of leucine. The lysosomal degradation of protein was reduced by only about 30% under the same conditions. These observations suggest that leucine is a major regulator of the bulk autophagy observable in the electron microscope, but that this type of autophagy contributes only about one-half of the total amount of protein degraded in lysosomes. Asparagine inhibited lysosomal protein degradation more strongly than did leucine, but had no significant effect on the amount of autophagic vacuoles. Leucine and asparagine would therefore seem to exert their effects on lysosomal protein degradation through different mechanisms." @default.
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- W2022003992 title "Leucine inhibition of autophagic vacuole formation in isolated rat hepatocytes" @default.
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- W2022003992 doi "https://doi.org/10.1016/0014-4827(81)90460-2" @default.
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