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• W2022004239 abstract "Intraepithelial intestinal T lymphocytes (IEL) bearing αβ or γδ T cell receptors (TCR) are positioned to serve as a first line of defense against enteric pathogens. To investigate whether intestinal IEL are subject to antigenic selective forces distinct from that influencing (xp T cells in the peripheral blood (PBL), we performed a comparative analysis of Vβ gene segment usage in IEL and PBL of immunologically normal donors by quantitative PCR. Primers for 22 different human TCR Vβ gene segments of Vβ gene segments families were used to analyze the repertoire of TCRβ chain transcripts in colonic IEL (c-IEL), in corresponding colonic lamina propria lymphocytes (c-LPL), and in peripheral blood lymphocytes. In each of the three individuals examined, a limited number (1–4 out of 22) of TCR Vβ families predominated and accounted for more than 50 % of the total β chain transcripts from c-IEL, whereas in PBL and c-LPL a more even distribution of Vβ gene families was observed. The dominating Vβ gene families were Vβ2, Vβ3, Vβ6, Vβ8 and Vβ14. In one individual, Vβ3 comprised more than 40 % of the entire repertoire of c-IEL β chain transcripts. Sequence analysis of the predominant Vβ3 family in this individual revealed identical sequences in 13 of 17 clones analyzed. Human αβTCR+ c-IEL could not be driven to proliferate or exhibit cytotoxic function in vitro however, PCR analysis for detection of lymphokine mRNA revealed constitutive production of several lymphokines known to exert trophic effects on intestinal epithelial cells and pro-inflammatory activities. Taken together, the striking degree of oligoclonality may indicate that the intraepithelial intestinal immune system is targeted to a limited set of hitherto unknown self- or foreign antigens present in the intestine and orchestrates intramucosal inflammatory and regenerative processes." @default.
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• W2022004239 date "1994-12-01" @default.
• W2022004239 modified "2023-10-12" @default.
• W2022004239 title "Oligoclonality and Skewed T Cell Receptor Vβ Gene Segment Expression in in vivo Activated Human Intestinal Intraepithelial T Lymphocytes" @default.
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• W2022004239 doi "https://doi.org/10.1016/s0171-2985(11)80409-2" @default.
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