FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022004671> ?p ?o ?g. }

• W2022004671 endingPage "17882" @default.
• W2022004671 startingPage "17877" @default.
• W2022004671 abstract "The integrity of the retinal pigment epithelial (RPE) cell is essential for the survival of rod and cone photoreceptor cells. Several stressors, including reactive oxygen species, trigger apoptotic damage in RPE cells preceded by an anti-inflammatory, pro-survival response, the formation of neuroprotectin D1 (NPD1), an oxygenation product derived from the essential omega-3 fatty acid family member docosahexaenoic acid. To define the ability of NPD1 and other endogenous novel lipid mediators in cell survival, we generated a stable knockdown human RPE (ARPE-19) cell line using short hairpin RNA to target 15-lipoxygenase-1. The 15-lipoxygenase-1-deficient cells exhibited 30% of the protein expression, and 15-lipoxygenase-2 remained unchanged, as compared with an ARPE-19 cell line control established using nonspecific short hairpin RNA transfected cells. NPD1 synthesis was stimulated by tumor necrosis factor alpha/H2O2-mediated oxidative stress in nonspecific cells (controls), whereas in silenced cells, negligible amounts of NPD1, 12(S)- and 15(S)-hydroxyeicosatetraenoic acid, and lipoxin A4 were found under these conditions. Neither control nor the deficient cells showed an increase in 15-lipoxygenase-1 protein content after 16 h of oxidative stress, suggesting that the increased activity of 15-lipoxygenase-1 is due to activation of pre-existing proteins. 15-Lipoxygenase-silenced cells also displayed an exacerbated sensitivity to oxidative stress-induced apoptosis when compared with the control cells. NPD1 selectively and potently rescued 15-lipoxygenase-silenced cells from oxidative stress-induced apoptosis. These results demonstrate that 15-lipoxygenase-1 is activated by oxidative stress in ARPE-19 cells and that NPD1 is part of an early survival signaling in RPE cells." @default.
• W2022004671 created "2016-06-24" @default.
• W2022004671 creator A5004716075 @default.
• W2022004671 creator A5043970877 @default.
• W2022004671 creator A5049239234 @default.
• W2022004671 creator A5068398524 @default.
• W2022004671 creator A5081277776 @default.
• W2022004671 creator A5087531111 @default.
• W2022004671 creator A5089915907 @default.
• W2022004671 date "2009-06-01" @default.
• W2022004671 modified "2023-10-14" @default.
• W2022004671 title "Selective Survival Rescue in 15-Lipoxygenase-1-deficient Retinal Pigment Epithelial Cells by the Novel Docosahexaenoic Acid-derived Mediator, Neuroprotectin D1" @default.
• W2022004671 cites W1739691545 @default.
• W2022004671 cites W1969871031 @default.
• W2022004671 cites W1990920941 @default.
• W2022004671 cites W2000498893 @default.
• W2022004671 cites W2005390270 @default.
• W2022004671 cites W2014271076 @default.
• W2022004671 cites W2016061176 @default.
• W2022004671 cites W2019772553 @default.
• W2022004671 cites W2028705982 @default.
• W2022004671 cites W2030136275 @default.
• W2022004671 cites W2040434386 @default.
• W2022004671 cites W2043004414 @default.
• W2022004671 cites W2048310961 @default.
• W2022004671 cites W2055277661 @default.
• W2022004671 cites W2057128909 @default.
• W2022004671 cites W2058488571 @default.
• W2022004671 cites W2061167233 @default.
• W2022004671 cites W2064839214 @default.
• W2022004671 cites W2068245819 @default.
• W2022004671 cites W2080495484 @default.
• W2022004671 cites W2092318471 @default.
• W2022004671 cites W2095239994 @default.
• W2022004671 cites W2100726346 @default.
• W2022004671 cites W2100837269 @default.
• W2022004671 cites W2111274886 @default.
• W2022004671 cites W2127130381 @default.
• W2022004671 cites W2141040327 @default.
• W2022004671 cites W2143187099 @default.
• W2022004671 cites W2157340973 @default.
• W2022004671 cites W2166102027 @default.
• W2022004671 cites W2215257582 @default.
• W2022004671 doi "https://doi.org/10.1074/jbc.m109.003988" @default.
• W2022004671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2719426" @default.
• W2022004671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19403949" @default.
• W2022004671 hasPublicationYear "2009" @default.
• W2022004671 type Work @default.
• W2022004671 sameAs 2022004671 @default.
• W2022004671 citedByCount "90" @default.
• W2022004671 countsByYear W20220046712012 @default.
• W2022004671 countsByYear W20220046712013 @default.
• W2022004671 countsByYear W20220046712014 @default.
• W2022004671 countsByYear W20220046712015 @default.
• W2022004671 countsByYear W20220046712016 @default.
• W2022004671 countsByYear W20220046712017 @default.
• W2022004671 countsByYear W20220046712018 @default.
• W2022004671 countsByYear W20220046712019 @default.
• W2022004671 countsByYear W20220046712020 @default.
• W2022004671 countsByYear W20220046712021 @default.
• W2022004671 countsByYear W20220046712022 @default.
• W2022004671 countsByYear W20220046712023 @default.
• W2022004671 crossrefType "journal-article" @default.
• W2022004671 hasAuthorship W2022004671A5004716075 @default.
• W2022004671 hasAuthorship W2022004671A5043970877 @default.
• W2022004671 hasAuthorship W2022004671A5049239234 @default.
• W2022004671 hasAuthorship W2022004671A5068398524 @default.
• W2022004671 hasAuthorship W2022004671A5081277776 @default.
• W2022004671 hasAuthorship W2022004671A5087531111 @default.
• W2022004671 hasAuthorship W2022004671A5089915907 @default.
• W2022004671 hasBestOaLocation W20220046711 @default.
• W2022004671 hasConcept C153911025 @default.
• W2022004671 hasConcept C180899940 @default.
• W2022004671 hasConcept C181199279 @default.
• W2022004671 hasConcept C190283241 @default.
• W2022004671 hasConcept C19038510 @default.
• W2022004671 hasConcept C2776151105 @default.
• W2022004671 hasConcept C2777171753 @default.
• W2022004671 hasConcept C2778078955 @default.
• W2022004671 hasConcept C2780857362 @default.
• W2022004671 hasConcept C31573885 @default.
• W2022004671 hasConcept C48349386 @default.
• W2022004671 hasConcept C54009773 @default.
• W2022004671 hasConcept C543025807 @default.
• W2022004671 hasConcept C54355233 @default.
• W2022004671 hasConcept C55493867 @default.
• W2022004671 hasConcept C81885089 @default.
• W2022004671 hasConcept C86803240 @default.
• W2022004671 hasConcept C90342290 @default.
• W2022004671 hasConcept C95444343 @default.
• W2022004671 hasConceptScore W2022004671C153911025 @default.
• W2022004671 hasConceptScore W2022004671C180899940 @default.
• W2022004671 hasConceptScore W2022004671C181199279 @default.
• W2022004671 hasConceptScore W2022004671C190283241 @default.
• W2022004671 hasConceptScore W2022004671C19038510 @default.
• W2022004671 hasConceptScore W2022004671C2776151105 @default.
• W2022004671 hasConceptScore W2022004671C2777171753 @default.
• W2022004671 hasConceptScore W2022004671C2778078955 @default.

• next