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- W2022019465 abstract "URINARY excretion of the serotonin metabolite, 5-hydroxyindolacetic acid, was studied both in normal subjects and in patients with a variety of diarrheal states. Three observations led to this investigation. Circulating 5-hydroxytryptamine (serotonin), which is secreted in large amounts by the tumor, causes the cramping abdominal pain and diarrhea of the malignant carcinoid syndrome.1 , 2 Parenterally administered serotonin has a marked effect upon the gut of man and animals.3 , 4 The precursor of serotonin, 5-hydroxytryptophan, produces nausea, abdominal cramps and borborygmi in human beings.5 Subjects and MethodsTwenty-four-hour specimens of urine were collected from 30 normal adults (house-staff and hospital personnel) and from . . ." @default.
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- W2022019465 date "1958-08-14" @default.
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- W2022019465 title "Urinary Excretion of 5-Hydroxyindolacetic Acid in Diarrheal States, with Special Reference to Nontropical Sprue" @default.
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- W2022019465 doi "https://doi.org/10.1056/nejm195808142590708" @default.
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