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• W2022020453 endingPage "1707" @default.
• W2022020453 startingPage "1703" @default.
• W2022020453 abstract "The kinetics of acetylcholine-receptor-mediated efflux of inorganic ions from electroplax microsacs of Electrophorus electricus in the presence of varying alkali metal ion concentrations on both sides of the membrane have been investigated. The efflux, a monophasic process when the ion distribution is symmetrical (the same concentrations and types of ions on both sides of the membrane), becomes a biphasic process, consisting of a very rapid initial release of ions followed by a slower first-order process, under conditions that resemble the physiological state of the neural membrane (potassium ions inside the microsacs and sodium ions on the outside). The initial phase of the efflux discriminates between calcium and sodium ions and is inhibited by potassium ions in the external solution. The rate constant associated with this phase is at least 40 times larger than the rate constant associated with the slower efflux. Both phases depend on the concentration of acetylcholine or carbamoylcholine, and are inhibited by receptor inhibitors (d-tubocurarine and alpha-bungarotoxin).A simple model is proposed which relates the kinetics of the flux to ligand-induced conformational changes in the receptor. We also indicate the relationship between the biphasic kinetics of the flux observed in microsacs to desensitization, the phenomenon in which, on addition of acetylcholine, the transmembrane voltage of muscle and nerve cells first increases and then decreases to its resting value within a few seconds." @default.
• W2022020453 created "2016-06-24" @default.
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• W2022020453 date "1978-04-01" @default.
• W2022020453 modified "2023-09-26" @default.
• W2022020453 title "Acetylcholine-receptor-mediated ion flux in electroplax membrane microsacs (vesicles): Change in mechanism produced by asymmetrical distribution of sodium and potassium ions" @default.
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• W2022020453 doi "https://doi.org/10.1073/pnas.75.4.1703" @default.
• W2022020453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/392407" @default.
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