Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022020620> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2022020620 endingPage "304" @default.
- W2022020620 startingPage "299" @default.
- W2022020620 abstract "The patch-clamp technique was used to investigate the effects of bis-benzylisoquinoline alkaloids on two of the major neuronal nicotinic acetylcholine receptors (nAChRs), the alpha3-containing nAChR (alpha3*nAChR) endogenously expressed in PC12 cells and the rat alpha7-nAChR heterologously expressed in GH4C1 cells. Tetrandrine and hernandezine reversibly inhibited both receptors displaying half-maximal inhibitory concentrations (IC50) of 8.1 microM and 5.8 microM for alpha3*nAChR and 407.4 nM and 372.2 nM, respectively, for alpha7-nAChR. E6-berbamine completely inhibited the alpha3*nAChR with an IC50 of 5.1 microM, but only partially inhibited the alpha7-nAChR at concentrations up to 30 microM. Tetrandrine inhibition of alpha3*nAChR was functionally non-competitive. All three compounds displaced radiolabelled methyllycaconitine ([3H]-MLA) binding to alpha7-nAChR providing some evidence of competitive antagonism. The results demonstrate that these alkaloids are nAChRs antagonists, with tetrandrine and hernandezine displaying selectivity for one of the major neuronal subtype, the alpha7 nAChR. The different potencies and multiple modes of action on nAChRs may help to better understand the pharmacology of these receptors and to aid in novel drug design." @default.
- W2022020620 created "2016-06-24" @default.
- W2022020620 creator A5017478342 @default.
- W2022020620 creator A5027552825 @default.
- W2022020620 creator A5048406456 @default.
- W2022020620 date "2005-06-01" @default.
- W2022020620 modified "2023-10-06" @default.
- W2022020620 title "Differential inhibition of rat α3* and α7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives" @default.
- W2022020620 cites W1970433428 @default.
- W2022020620 cites W1971611960 @default.
- W2022020620 cites W1991870284 @default.
- W2022020620 cites W1995888798 @default.
- W2022020620 cites W1995966608 @default.
- W2022020620 cites W1999952388 @default.
- W2022020620 cites W2005494042 @default.
- W2022020620 cites W2013305466 @default.
- W2022020620 cites W2024776462 @default.
- W2022020620 cites W2030825535 @default.
- W2022020620 cites W2070182904 @default.
- W2022020620 cites W2086647542 @default.
- W2022020620 cites W2095448505 @default.
- W2022020620 cites W2408706035 @default.
- W2022020620 doi "https://doi.org/10.1016/j.neulet.2005.02.035" @default.
- W2022020620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15896488" @default.
- W2022020620 hasPublicationYear "2005" @default.
- W2022020620 type Work @default.
- W2022020620 sameAs 2022020620 @default.
- W2022020620 citedByCount "9" @default.
- W2022020620 countsByYear W20220206202016 @default.
- W2022020620 countsByYear W20220206202017 @default.
- W2022020620 countsByYear W20220206202019 @default.
- W2022020620 countsByYear W20220206202022 @default.
- W2022020620 countsByYear W20220206202023 @default.
- W2022020620 crossrefType "journal-article" @default.
- W2022020620 hasAuthorship W2022020620A5017478342 @default.
- W2022020620 hasAuthorship W2022020620A5027552825 @default.
- W2022020620 hasAuthorship W2022020620A5048406456 @default.
- W2022020620 hasBestOaLocation W20220206201 @default.
- W2022020620 hasConcept C104292427 @default.
- W2022020620 hasConcept C104317684 @default.
- W2022020620 hasConcept C170493617 @default.
- W2022020620 hasConcept C181199279 @default.
- W2022020620 hasConcept C185592680 @default.
- W2022020620 hasConcept C188987157 @default.
- W2022020620 hasConcept C2776104367 @default.
- W2022020620 hasConcept C2777667214 @default.
- W2022020620 hasConcept C2779570518 @default.
- W2022020620 hasConcept C2779733990 @default.
- W2022020620 hasConcept C2779934757 @default.
- W2022020620 hasConcept C2780374058 @default.
- W2022020620 hasConcept C2909754679 @default.
- W2022020620 hasConcept C553450214 @default.
- W2022020620 hasConcept C55493867 @default.
- W2022020620 hasConcept C71240020 @default.
- W2022020620 hasConcept C80161118 @default.
- W2022020620 hasConcept C86803240 @default.
- W2022020620 hasConcept C98274493 @default.
- W2022020620 hasConceptScore W2022020620C104292427 @default.
- W2022020620 hasConceptScore W2022020620C104317684 @default.
- W2022020620 hasConceptScore W2022020620C170493617 @default.
- W2022020620 hasConceptScore W2022020620C181199279 @default.
- W2022020620 hasConceptScore W2022020620C185592680 @default.
- W2022020620 hasConceptScore W2022020620C188987157 @default.
- W2022020620 hasConceptScore W2022020620C2776104367 @default.
- W2022020620 hasConceptScore W2022020620C2777667214 @default.
- W2022020620 hasConceptScore W2022020620C2779570518 @default.
- W2022020620 hasConceptScore W2022020620C2779733990 @default.
- W2022020620 hasConceptScore W2022020620C2779934757 @default.
- W2022020620 hasConceptScore W2022020620C2780374058 @default.
- W2022020620 hasConceptScore W2022020620C2909754679 @default.
- W2022020620 hasConceptScore W2022020620C553450214 @default.
- W2022020620 hasConceptScore W2022020620C55493867 @default.
- W2022020620 hasConceptScore W2022020620C71240020 @default.
- W2022020620 hasConceptScore W2022020620C80161118 @default.
- W2022020620 hasConceptScore W2022020620C86803240 @default.
- W2022020620 hasConceptScore W2022020620C98274493 @default.
- W2022020620 hasIssue "3" @default.
- W2022020620 hasLocation W20220206201 @default.
- W2022020620 hasLocation W20220206202 @default.
- W2022020620 hasOpenAccess W2022020620 @default.
- W2022020620 hasPrimaryLocation W20220206201 @default.
- W2022020620 hasRelatedWork W2023479520 @default.
- W2022020620 hasRelatedWork W2026430121 @default.
- W2022020620 hasRelatedWork W2057551724 @default.
- W2022020620 hasRelatedWork W2061901670 @default.
- W2022020620 hasRelatedWork W2078684157 @default.
- W2022020620 hasRelatedWork W2092426740 @default.
- W2022020620 hasRelatedWork W2101590601 @default.
- W2022020620 hasRelatedWork W2151798397 @default.
- W2022020620 hasRelatedWork W3029179371 @default.
- W2022020620 hasRelatedWork W4296046054 @default.
- W2022020620 hasVolume "381" @default.
- W2022020620 isParatext "false" @default.
- W2022020620 isRetracted "false" @default.
- W2022020620 magId "2022020620" @default.
- W2022020620 workType "article" @default.