FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022020723> ?p ?o ?g. }

• W2022020723 endingPage "757" @default.
• W2022020723 startingPage "743" @default.
• W2022020723 abstract "Systemic administration of growth hormone-releasing hormone (GHRH) has been found to improve human sleep in previous studies. Here we examined effects of GHRH on endocrine function and sleep after intranasal administration, a method which based on previous studies appears to enable a direct effect of peptides on brain function. Also, it was hypothesized that elderly humans displaying deficient GH release and sleep, benefit from GHRH administration more than young subjects. A study was performed according to a double-blind cross-over design. Each of 12 young and 11 old healthy men were intranasally administered with 300 μg GHRH (vs. placebo) 30 min before bedtime at 23:00 h. Sleep was recorded polysomnographically until 07:00 h and blood was collected in 15 min intervals for determination of cortisol and GH. Apart from the well-known age-related changes of hormonal secretion and sleep, intranasal GHRH reduced cortisol nadir concentrations in the beginning of sleep (P<0.05), and also reduced the sleep-induced elevation in GH concentrations during early sleep. Moreover, results indicated that after intranasal administration GHRH increased rapid-eye-movement (REM) sleep and slow wave sleep (SWS), with this influence concentrating on the second half of sleep time. Effects of GHRH did not depend on the subject’s age. We conclude that there is a coordinate influence of intranasal GHRH on the central nervous regulation of sleep processes and of hypothalamic–hypophysiotropic secretory activity in both young and elderly men. The effects may mimic the dual neuronal and endocrine function of hypothalamic GHRH activity." @default.
• W2022020723 created "2016-06-24" @default.
• W2022020723 creator A5007263253 @default.
• W2022020723 creator A5016165867 @default.
• W2022020723 creator A5036040037 @default.
• W2022020723 creator A5069919212 @default.
• W2022020723 creator A5073905698 @default.
• W2022020723 date "1999-10-01" @default.
• W2022020723 modified "2023-10-16" @default.
• W2022020723 title "Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans" @default.
• W2022020723 cites W1964005327 @default.
• W2022020723 cites W1967262708 @default.
• W2022020723 cites W1971996869 @default.
• W2022020723 cites W1974420112 @default.
• W2022020723 cites W1979710595 @default.
• W2022020723 cites W1982128334 @default.
• W2022020723 cites W1984338835 @default.
• W2022020723 cites W1989203969 @default.
• W2022020723 cites W1991232931 @default.
• W2022020723 cites W1995277808 @default.
• W2022020723 cites W2002221507 @default.
• W2022020723 cites W2005337519 @default.
• W2022020723 cites W2007135601 @default.
• W2022020723 cites W2013810547 @default.
• W2022020723 cites W2015757620 @default.
• W2022020723 cites W2017160384 @default.
• W2022020723 cites W2024747558 @default.
• W2022020723 cites W2028519527 @default.
• W2022020723 cites W2030846155 @default.
• W2022020723 cites W2033912043 @default.
• W2022020723 cites W2035278854 @default.
• W2022020723 cites W2051067576 @default.
• W2022020723 cites W2057792489 @default.
• W2022020723 cites W2059023753 @default.
• W2022020723 cites W2064396393 @default.
• W2022020723 cites W2071796624 @default.
• W2022020723 cites W2072714418 @default.
• W2022020723 cites W2083352270 @default.
• W2022020723 cites W2085305367 @default.
• W2022020723 cites W2086405833 @default.
• W2022020723 cites W2102375891 @default.
• W2022020723 cites W2149381553 @default.
• W2022020723 cites W2155671488 @default.
• W2022020723 cites W2158036799 @default.
• W2022020723 cites W2326301338 @default.
• W2022020723 doi "https://doi.org/10.1016/s0306-4530(99)00027-x" @default.
• W2022020723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10451909" @default.
• W2022020723 hasPublicationYear "1999" @default.
• W2022020723 type Work @default.
• W2022020723 sameAs 2022020723 @default.
• W2022020723 citedByCount "74" @default.
• W2022020723 countsByYear W20220207232012 @default.
• W2022020723 countsByYear W20220207232013 @default.
• W2022020723 countsByYear W20220207232014 @default.
• W2022020723 countsByYear W20220207232015 @default.
• W2022020723 countsByYear W20220207232016 @default.
• W2022020723 countsByYear W20220207232017 @default.
• W2022020723 countsByYear W20220207232018 @default.
• W2022020723 countsByYear W20220207232019 @default.
• W2022020723 countsByYear W20220207232020 @default.
• W2022020723 countsByYear W20220207232021 @default.
• W2022020723 countsByYear W20220207232022 @default.
• W2022020723 countsByYear W20220207232023 @default.
• W2022020723 crossrefType "journal-article" @default.
• W2022020723 hasAuthorship W2022020723A5007263253 @default.
• W2022020723 hasAuthorship W2022020723A5016165867 @default.
• W2022020723 hasAuthorship W2022020723A5036040037 @default.
• W2022020723 hasAuthorship W2022020723A5069919212 @default.
• W2022020723 hasAuthorship W2022020723A5073905698 @default.
• W2022020723 hasConcept C110539466 @default.
• W2022020723 hasConcept C111919701 @default.
• W2022020723 hasConcept C126322002 @default.
• W2022020723 hasConcept C134018914 @default.
• W2022020723 hasConcept C153050134 @default.
• W2022020723 hasConcept C15744967 @default.
• W2022020723 hasConcept C169760540 @default.
• W2022020723 hasConcept C2775841894 @default.
• W2022020723 hasConcept C2778205975 @default.
• W2022020723 hasConcept C2778537899 @default.
• W2022020723 hasConcept C2779213384 @default.
• W2022020723 hasConcept C2781042741 @default.
• W2022020723 hasConcept C2781326671 @default.
• W2022020723 hasConcept C2910364982 @default.
• W2022020723 hasConcept C2984496839 @default.
• W2022020723 hasConcept C41008148 @default.
• W2022020723 hasConcept C46699223 @default.
• W2022020723 hasConcept C522805319 @default.
• W2022020723 hasConcept C71315377 @default.
• W2022020723 hasConcept C71924100 @default.
• W2022020723 hasConcept C85663871 @default.
• W2022020723 hasConcept C98274493 @default.
• W2022020723 hasConceptScore W2022020723C110539466 @default.
• W2022020723 hasConceptScore W2022020723C111919701 @default.
• W2022020723 hasConceptScore W2022020723C126322002 @default.
• W2022020723 hasConceptScore W2022020723C134018914 @default.
• W2022020723 hasConceptScore W2022020723C153050134 @default.
• W2022020723 hasConceptScore W2022020723C15744967 @default.
• W2022020723 hasConceptScore W2022020723C169760540 @default.

• next