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- W2022021472 abstract "The clinical pharmacokinetics of amitriptyline were studied in four volunteers after the oral administration of 75 mg. Peak amitriptyline plasma concentrations ranged from 10.8 to 43.7 ng/ml. The disappearance was biphasic and followed first-order kinetics. The mean elimination half-life was 36.1 hours. The mean estimated first-pass metabolism of amitriptyline was 60 per cent. Significant quantities of the metabolite, nortriptyline, were produced although peak concentrations ranged from only 5.9 to 12.3 ng/ml. The relationship between these findings to clinical practice and earlier reports is discussed." @default.
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- W2022021472 date "1978-10-01" @default.
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- W2022021472 title "Contribution to the Pharmacokinetics of Amitriptyline" @default.
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- W2022021472 doi "https://doi.org/10.1002/j.1552-4604.1978.tb01572.x" @default.
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