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- W2022022418 abstract "Excessive postoperative bleeding during cardiac surgery calls for transfusions of allogeneic blood products, and up to 5% of patients undergoing coronary artery bypass grafting and 10% of those undergoing more complex heart surgery need early reoperation to control haemorrhage. Reoperation for bleeding increases hospital mortality and postoperative morbidity by three or four times, substantially increases hospital stay, and has a sizeable effect on health-care costs. Effect of aprotinin on renal dysfunction in patients undergoing on-pump and off-pump cardiac surgery: a retrospective observational studyOur results have shown that aprotinin seems to be safe during on-pump cardiac surgery. However, the combination of aprotinin and ACE inhibitors during off-pump cardiac surgery is associated with a significant risk of postoperative renal dysfunction. Full-Text PDF" @default.
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- W2022022418 date "2008-02-01" @default.
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- W2022022418 title "Aprotinin—still courting controversy" @default.
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- W2022022418 doi "https://doi.org/10.1016/s0140-6736(08)60212-3" @default.
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