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- W2022025085 abstract "Regulation of gene expression involves long-distance communication between regulatory elements and target promoters, but how this is achieved remains unknown. Insulator elements have been proposed to modulate the communication between regulatory elements and promoters due to their ability to insulate genes from regulatory elements or to take part in long-distance interactions. Using a high-resolution chromatin conformation capture (H3C) method, we show that the Drosophila gypsy insulator behaves as a conformational chromatin border that is able to prohibit contacts between a Polycomb response element (PRE) and a distal promoter. On the other hand, two spaced gypsy elements form a chromatin loop that is able to bring an upstream PRE in contact with a downstream gene to mediate its repression. Chromatin immunoprecipitation (ChIP) profiles of the Polycomb protein and its associated H3K27me3 histone mark reflect this insulator-dependent chromatin conformation, suggesting that Polycomb action at a distance can be organized by local chromatin topology." @default.
- W2022025085 created "2016-06-24" @default.
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- W2022025085 date "2011-01-24" @default.
- W2022025085 modified "2023-10-10" @default.
- W2022025085 title "A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber" @default.
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- W2022025085 doi "https://doi.org/10.1073/pnas.1002059108" @default.
- W2022025085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3038747" @default.
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