FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022025102> ?p ?o ?g. }

• W2022025102 endingPage "1210" @default.
• W2022025102 startingPage "1202" @default.
• W2022025102 abstract "BACKGROUND Alterations in nuclei structure and DNA content captured from Gleason grading patterns 3, 4 and 5 of radical prostatectomy (RP) cases were determined by a computer-assisted microscope. Quantitative Nuclear Morphometry (QNM) profiles were created to evaluate variability in nuclear structure within each of these grades. METHODS A tissue microarray (TMA) was constructed using RP cases and the prostate cancer (PCa) TMA cores prepared from 20 GG-3, 9 GG-4, 10 GG-5 patterns, and 20 benign cancer-adjacent cases from RP archival paraffin blocks. Feulgen-stained nuclei were captured from 0.6 mm spots using the AutoCyte™ system. Pools of 1100 nuclei captured from each test group were used to calculate Multivariate Logistic Regression (MLR) models that generated predictive indices and predictive probabilities (PP) to make comparisons between and within each set of pooled nuclei. RESULTS A single QNM profiles yielded areas of receiver operator characteristic curves (ROC) that distinguished differences among benign cancer-adjacent nuclei and GG-3 (ROC-AUC = 0.78); GG-4 (ROC-AUC = 0.86) and GG-5 (ROC-AUC = 0.88) with accuracies of 73%, 78% and 80% respectively. Applying PP plots generated from MLR models of GG 3, 4, and 5 nuclei clearly demonstrated marked heterogeneity within each of these three GG patterns. CONCLUSIONS QNM signatures illustrate alterations in nuclei structure, based upon nuclear morphometry within each of these three GG patterns, and might signify potential variations in PCa disease risk of progression outcomes. In the future a modified system of Gleason grading that considers not only glandular architecture but also quantitative nuclear grade may ensure accuracy in prognosis. Prostate 67: 1202–1210, 2007. © 2007 Wiley-Liss, Inc." @default.
• W2022025102 created "2016-06-24" @default.
• W2022025102 creator A5003287905 @default.
• W2022025102 creator A5035137850 @default.
• W2022025102 creator A5040610145 @default.
• W2022025102 creator A5062227791 @default.
• W2022025102 creator A5063449536 @default.
• W2022025102 creator A5073431093 @default.
• W2022025102 date "2007-01-01" @default.
• W2022025102 modified "2023-09-27" @default.
• W2022025102 title "Significant variations in nuclear structure occur between and within Gleason grading patterns 3, 4, and 5 determined by digital image analysis" @default.
• W2022025102 cites W1537530862 @default.
• W2022025102 cites W1571849492 @default.
• W2022025102 cites W1761607732 @default.
• W2022025102 cites W1971949046 @default.
• W2022025102 cites W1973951614 @default.
• W2022025102 cites W1978216056 @default.
• W2022025102 cites W1978818466 @default.
• W2022025102 cites W1979649251 @default.
• W2022025102 cites W1984829389 @default.
• W2022025102 cites W1987876107 @default.
• W2022025102 cites W1996605667 @default.
• W2022025102 cites W2003675536 @default.
• W2022025102 cites W2006115709 @default.
• W2022025102 cites W2011120797 @default.
• W2022025102 cites W2014740668 @default.
• W2022025102 cites W2037125565 @default.
• W2022025102 cites W2039250830 @default.
• W2022025102 cites W2057295518 @default.
• W2022025102 cites W2062213137 @default.
• W2022025102 cites W2062548587 @default.
• W2022025102 cites W2070862000 @default.
• W2022025102 cites W2082593613 @default.
• W2022025102 cites W2087788603 @default.
• W2022025102 cites W2105548709 @default.
• W2022025102 cites W2109046819 @default.
• W2022025102 cites W2117792530 @default.
• W2022025102 cites W2127031670 @default.
• W2022025102 cites W2129020851 @default.
• W2022025102 cites W2134807295 @default.
• W2022025102 cites W2142893184 @default.
• W2022025102 cites W2156776019 @default.
• W2022025102 cites W2160209118 @default.
• W2022025102 cites W2163144362 @default.
• W2022025102 cites W2209020482 @default.
• W2022025102 cites W2312499024 @default.
• W2022025102 cites W3023689102 @default.
• W2022025102 doi "https://doi.org/10.1002/pros.20614" @default.
• W2022025102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17525934" @default.
• W2022025102 hasPublicationYear "2007" @default.
• W2022025102 type Work @default.
• W2022025102 sameAs 2022025102 @default.
• W2022025102 citedByCount "22" @default.
• W2022025102 countsByYear W20220251022012 @default.
• W2022025102 countsByYear W20220251022013 @default.
• W2022025102 countsByYear W20220251022014 @default.
• W2022025102 countsByYear W20220251022015 @default.
• W2022025102 countsByYear W20220251022016 @default.
• W2022025102 countsByYear W20220251022017 @default.
• W2022025102 countsByYear W20220251022018 @default.
• W2022025102 crossrefType "journal-article" @default.
• W2022025102 hasAuthorship W2022025102A5003287905 @default.
• W2022025102 hasAuthorship W2022025102A5035137850 @default.
• W2022025102 hasAuthorship W2022025102A5040610145 @default.
• W2022025102 hasAuthorship W2022025102A5062227791 @default.
• W2022025102 hasAuthorship W2022025102A5063449536 @default.
• W2022025102 hasAuthorship W2022025102A5073431093 @default.
• W2022025102 hasConcept C121608353 @default.
• W2022025102 hasConcept C126322002 @default.
• W2022025102 hasConcept C142724271 @default.
• W2022025102 hasConcept C151956035 @default.
• W2022025102 hasConcept C18903297 @default.
• W2022025102 hasConcept C2776235491 @default.
• W2022025102 hasConcept C2777286243 @default.
• W2022025102 hasConcept C2777522853 @default.
• W2022025102 hasConcept C2779466945 @default.
• W2022025102 hasConcept C2780192828 @default.
• W2022025102 hasConcept C2909954168 @default.
• W2022025102 hasConcept C2989005 @default.
• W2022025102 hasConcept C31972630 @default.
• W2022025102 hasConcept C41008148 @default.
• W2022025102 hasConcept C58471807 @default.
• W2022025102 hasConcept C71924100 @default.
• W2022025102 hasConcept C86803240 @default.
• W2022025102 hasConceptScore W2022025102C121608353 @default.
• W2022025102 hasConceptScore W2022025102C126322002 @default.
• W2022025102 hasConceptScore W2022025102C142724271 @default.
• W2022025102 hasConceptScore W2022025102C151956035 @default.
• W2022025102 hasConceptScore W2022025102C18903297 @default.
• W2022025102 hasConceptScore W2022025102C2776235491 @default.
• W2022025102 hasConceptScore W2022025102C2777286243 @default.
• W2022025102 hasConceptScore W2022025102C2777522853 @default.
• W2022025102 hasConceptScore W2022025102C2779466945 @default.
• W2022025102 hasConceptScore W2022025102C2780192828 @default.
• W2022025102 hasConceptScore W2022025102C2909954168 @default.
• W2022025102 hasConceptScore W2022025102C2989005 @default.
• W2022025102 hasConceptScore W2022025102C31972630 @default.
• W2022025102 hasConceptScore W2022025102C41008148 @default.

• next