FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022026140> ?p ?o ?g. }

• W2022026140 endingPage "164" @default.
• W2022026140 startingPage "160" @default.
• W2022026140 abstract "Serotonin (5-HT) can constrict cerebral arteries via activation of 5-HT1B and 5-HT2A receptors. Our goal was to reveal the importance and relative contribution of the two 5-HT receptor subtypes to the serotonin-induced vasoconstriction in the rat middle cerebral artery. The vasoconstrictor effects of 5-carboxamidotryptamine, sumatriptan and 5-HT were measured without and with pre-treatment with SB 216641 (5-HT1B antagonist), or ritanserin, (5-HT2A antagonist), in endothelium-denuded arteries, in vitro. All agonists caused vasoconstrictions. The order of potency (EC50) of the compounds was: 5-carboxamidotryptamine (14±3 nM)>5-HT (270±30 nM)>sumatriptan (5.8±1.9 μM). The concentration–response curve of 5-carboxamidotryptamine resembled the sum of two sigmoid curves (EC50 14±3 nM and 15±7 μM), and SB 216641 and ritanserin antagonized its low and high concentration components, respectively. Vasoconstrictions evoked by 5-HT at low and high concentrations were also fully antagonized by SB 216641 and ritanserin, respectively. Sumatriptan constricted the middle cerebral artery exclusively via 5-HT1B receptors. The efficacy of 5-carboxamidotryptamine and sumatriptan was low in comparison to the maximum contractile force elicited by 120 mmol/l KCl, reaching only 18–23% for 5-HT1B and 14% for 5-HT2A receptor activation. In conclusion, 5-HT produced small vasoconstrictions in the rat middle cerebral artery that were mediated by 5-HT1B receptors with high potency and by 5-HT2A receptors with low potency. Thus, 5-HT may have a minor physiological role in blood flow regulation via 5-HT1B receptor activation while 5-HT2A receptors seem to have a pathophysiological role in this vessel." @default.
• W2022026140 created "2016-06-24" @default.
• W2022026140 creator A5051576670 @default.
• W2022026140 creator A5051767811 @default.
• W2022026140 creator A5069196471 @default.
• W2022026140 date "2012-08-01" @default.
• W2022026140 modified "2023-10-14" @default.
• W2022026140 title "Vasoconstrictor 5-HT receptors in the smooth muscle of the rat middle cerebral artery" @default.
• W2022026140 cites W1510864746 @default.
• W2022026140 cites W1953204375 @default.
• W2022026140 cites W1968362236 @default.
• W2022026140 cites W1970445852 @default.
• W2022026140 cites W1972820606 @default.
• W2022026140 cites W1976782762 @default.
• W2022026140 cites W1985685139 @default.
• W2022026140 cites W1986040727 @default.
• W2022026140 cites W1986857690 @default.
• W2022026140 cites W1987425562 @default.
• W2022026140 cites W1990790730 @default.
• W2022026140 cites W1993448030 @default.
• W2022026140 cites W1994027741 @default.
• W2022026140 cites W1995940324 @default.
• W2022026140 cites W2008915415 @default.
• W2022026140 cites W2011181015 @default.
• W2022026140 cites W2012508148 @default.
• W2022026140 cites W2024071816 @default.
• W2022026140 cites W2031063112 @default.
• W2022026140 cites W2041140675 @default.
• W2022026140 cites W2042745003 @default.
• W2022026140 cites W2053561093 @default.
• W2022026140 cites W2068253450 @default.
• W2022026140 cites W2069466951 @default.
• W2022026140 cites W2069610052 @default.
• W2022026140 cites W2074889808 @default.
• W2022026140 cites W2078534487 @default.
• W2022026140 cites W2081906151 @default.
• W2022026140 cites W2084559769 @default.
• W2022026140 cites W2094514686 @default.
• W2022026140 cites W2100561602 @default.
• W2022026140 cites W2102231552 @default.
• W2022026140 cites W2105111481 @default.
• W2022026140 cites W2120320717 @default.
• W2022026140 cites W2121473111 @default.
• W2022026140 cites W2127586560 @default.
• W2022026140 cites W2150392466 @default.
• W2022026140 cites W2151192281 @default.
• W2022026140 cites W2152771767 @default.
• W2022026140 cites W2157432035 @default.
• W2022026140 cites W2159601487 @default.
• W2022026140 cites W2159973621 @default.
• W2022026140 cites W2167525800 @default.
• W2022026140 doi "https://doi.org/10.1016/j.ejphar.2012.05.031" @default.
• W2022026140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22659115" @default.
• W2022026140 hasPublicationYear "2012" @default.
• W2022026140 type Work @default.
• W2022026140 sameAs 2022026140 @default.
• W2022026140 citedByCount "13" @default.
• W2022026140 countsByYear W20220261402014 @default.
• W2022026140 countsByYear W20220261402015 @default.
• W2022026140 countsByYear W20220261402018 @default.
• W2022026140 countsByYear W20220261402019 @default.
• W2022026140 countsByYear W20220261402020 @default.
• W2022026140 countsByYear W20220261402023 @default.
• W2022026140 crossrefType "journal-article" @default.
• W2022026140 hasAuthorship W2022026140A5051576670 @default.
• W2022026140 hasAuthorship W2022026140A5051767811 @default.
• W2022026140 hasAuthorship W2022026140A5069196471 @default.
• W2022026140 hasConcept C119671327 @default.
• W2022026140 hasConcept C126322002 @default.
• W2022026140 hasConcept C134018914 @default.
• W2022026140 hasConcept C170493617 @default.
• W2022026140 hasConcept C171614378 @default.
• W2022026140 hasConcept C185592680 @default.
• W2022026140 hasConcept C202751555 @default.
• W2022026140 hasConcept C2775864247 @default.
• W2022026140 hasConcept C2776885963 @default.
• W2022026140 hasConcept C2777450907 @default.
• W2022026140 hasConcept C2777785214 @default.
• W2022026140 hasConcept C2778122271 @default.
• W2022026140 hasConcept C2778871607 @default.
• W2022026140 hasConcept C2778938600 @default.
• W2022026140 hasConcept C2779961880 @default.
• W2022026140 hasConcept C53910766 @default.
• W2022026140 hasConcept C55493867 @default.
• W2022026140 hasConcept C57992300 @default.
• W2022026140 hasConcept C71924100 @default.
• W2022026140 hasConcept C86803240 @default.
• W2022026140 hasConceptScore W2022026140C119671327 @default.
• W2022026140 hasConceptScore W2022026140C126322002 @default.
• W2022026140 hasConceptScore W2022026140C134018914 @default.
• W2022026140 hasConceptScore W2022026140C170493617 @default.
• W2022026140 hasConceptScore W2022026140C171614378 @default.
• W2022026140 hasConceptScore W2022026140C185592680 @default.
• W2022026140 hasConceptScore W2022026140C202751555 @default.
• W2022026140 hasConceptScore W2022026140C2775864247 @default.
• W2022026140 hasConceptScore W2022026140C2776885963 @default.
• W2022026140 hasConceptScore W2022026140C2777450907 @default.
• W2022026140 hasConceptScore W2022026140C2777785214 @default.

• next