FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022026939> ?p ?o ?g. }

• W2022026939 endingPage "e108377" @default.
• W2022026939 startingPage "e108377" @default.
• W2022026939 abstract "Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that infects a variety of mammals, including humans. An effective vaccine for this parasite is therefore needed. In this study, RH strain T. gondii rhoptry protein 17 was expressed in bacteria as a fusion with glutathione S-transferase (GST) and the recombinant proteins (rTgROP17) were purified via GST-affinity chromatography. BALB/c mice were nasally immunised with rTgROP17, and induction of immune responses and protection against chronic and lethal T. gondii infections were investigated. The results revealed that mice immunised with rTgROP17 produced high levels of specific anti-rTgROP17 IgGs and a mixed IgG1/IgG2a response of IgG2a predominance. The systemic immune response was associated with increased production of Th1 (IFN-γand IL-2) and Th2 (IL-4) cytokines, and enhanced lymphoproliferation (stimulation index, SI) in the mice immunised with rTgROP17. Strong mucosal immune responses with increased secretion of TgROP17-specific secretory IgA (SIgA) in nasal, vaginal and intestinal washes were also observed in these mice. The vaccinated mice displayed apparent protection against chronic RH strain infection as evidenced by their lower liver and brain parasite burdens (59.17% and 49.08%, respectively) than those of the controls. The vaccinated mice also exhibited significant protection against lethal infection of the virulent RH strain (survival increased by 50%) compared to the controls. Our data demonstrate that rTgROP17 can trigger strong systemic and mucosal immune responses against T. gondii and that ROP17 is a promising candidate vaccine for toxoplasmosis." @default.
• W2022026939 created "2016-06-24" @default.
• W2022026939 creator A5009312447 @default.
• W2022026939 creator A5014810570 @default.
• W2022026939 creator A5026494857 @default.
• W2022026939 creator A5031069096 @default.
• W2022026939 creator A5031076949 @default.
• W2022026939 creator A5034961174 @default.
• W2022026939 creator A5041588764 @default.
• W2022026939 creator A5042316902 @default.
• W2022026939 creator A5057721984 @default.
• W2022026939 creator A5079040679 @default.
• W2022026939 creator A5079553213 @default.
• W2022026939 date "2014-09-25" @default.
• W2022026939 modified "2023-09-27" @default.
• W2022026939 title "Partial Protective Effect of Intranasal Immunization with Recombinant Toxoplasma gondii Rhoptry Protein 17 against Toxoplasmosis in Mice" @default.
• W2022026939 cites W1571840817 @default.
• W2022026939 cites W1571960952 @default.
• W2022026939 cites W1800833779 @default.
• W2022026939 cites W1898034247 @default.
• W2022026939 cites W1935780090 @default.
• W2022026939 cites W1970998121 @default.
• W2022026939 cites W1971636796 @default.
• W2022026939 cites W1974120598 @default.
• W2022026939 cites W1991135195 @default.
• W2022026939 cites W1992757029 @default.
• W2022026939 cites W1992935467 @default.
• W2022026939 cites W1996130689 @default.
• W2022026939 cites W1996355227 @default.
• W2022026939 cites W1997446599 @default.
• W2022026939 cites W2006994926 @default.
• W2022026939 cites W2011640853 @default.
• W2022026939 cites W2013679658 @default.
• W2022026939 cites W2015703705 @default.
• W2022026939 cites W2016105709 @default.
• W2022026939 cites W2018689806 @default.
• W2022026939 cites W2021105093 @default.
• W2022026939 cites W2025856007 @default.
• W2022026939 cites W2031404476 @default.
• W2022026939 cites W2031719384 @default.
• W2022026939 cites W2039184339 @default.
• W2022026939 cites W2042990958 @default.
• W2022026939 cites W2043143775 @default.
• W2022026939 cites W2045214907 @default.
• W2022026939 cites W2046190332 @default.
• W2022026939 cites W2050263490 @default.
• W2022026939 cites W2054519950 @default.
• W2022026939 cites W2064996606 @default.
• W2022026939 cites W2065654101 @default.
• W2022026939 cites W2075533580 @default.
• W2022026939 cites W2075744120 @default.
• W2022026939 cites W2082431690 @default.
• W2022026939 cites W2087001215 @default.
• W2022026939 cites W2090349233 @default.
• W2022026939 cites W2109480257 @default.
• W2022026939 cites W2110729358 @default.
• W2022026939 cites W2114241062 @default.
• W2022026939 cites W2117873437 @default.
• W2022026939 cites W2125829950 @default.
• W2022026939 cites W2133868033 @default.
• W2022026939 cites W2142713800 @default.
• W2022026939 cites W2142788740 @default.
• W2022026939 cites W2150841475 @default.
• W2022026939 cites W2153513949 @default.
• W2022026939 cites W2154767199 @default.
• W2022026939 cites W2163436968 @default.
• W2022026939 cites W2167144821 @default.
• W2022026939 cites W2168752254 @default.
• W2022026939 cites W2169675047 @default.
• W2022026939 cites W4211140781 @default.
• W2022026939 doi "https://doi.org/10.1371/journal.pone.0108377" @default.
• W2022026939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177930" @default.
• W2022026939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25255141" @default.
• W2022026939 hasPublicationYear "2014" @default.
• W2022026939 type Work @default.
• W2022026939 sameAs 2022026939 @default.
• W2022026939 citedByCount "21" @default.
• W2022026939 countsByYear W20220269392015 @default.
• W2022026939 countsByYear W20220269392016 @default.
• W2022026939 countsByYear W20220269392017 @default.
• W2022026939 countsByYear W20220269392018 @default.
• W2022026939 countsByYear W20220269392019 @default.
• W2022026939 countsByYear W20220269392020 @default.
• W2022026939 countsByYear W20220269392021 @default.
• W2022026939 countsByYear W20220269392023 @default.
• W2022026939 crossrefType "journal-article" @default.
• W2022026939 hasAuthorship W2022026939A5009312447 @default.
• W2022026939 hasAuthorship W2022026939A5014810570 @default.
• W2022026939 hasAuthorship W2022026939A5026494857 @default.
• W2022026939 hasAuthorship W2022026939A5031069096 @default.
• W2022026939 hasAuthorship W2022026939A5031076949 @default.
• W2022026939 hasAuthorship W2022026939A5034961174 @default.
• W2022026939 hasAuthorship W2022026939A5041588764 @default.
• W2022026939 hasAuthorship W2022026939A5042316902 @default.
• W2022026939 hasAuthorship W2022026939A5057721984 @default.
• W2022026939 hasAuthorship W2022026939A5079040679 @default.
• W2022026939 hasAuthorship W2022026939A5079553213 @default.
• W2022026939 hasBestOaLocation W20220269391 @default.

• next