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- W202202699 abstract "Recent studies1-5 have revealed several time-adaptive components in the classic Hering-Breuer inflation reflex (HBIR)6,7 modulation of the respiratory rhythm elicited by lung inflation or electrical vagal stimulation. The primary adaptive component features a slow exponential decay that evidences a gradual habituation of HBIR, possibly due to time-dependent adaptations in the primary central pathway for neurotransmission of vagal-volume feedback (VVF) to the respiratory central pattern generator (RCPG). A secondary adaptive component is characterized by an abrupt post-stimulus rebound and exponential recovery of the respiratory rhythm following the cessation of the vagal input, an effect that has been linked to NMDA receptor-dependent desensitization of neurotransmission in a secondary vagally-modulated pathway via the pontine pneumotaxic region.3,4 The combined habituation-desensitization of HBIR via the primary and secondary central pathways conform with the classic dual-process model of nonassociative learning 4,8 These observations provide the first indication that nonassociative learning may play a role in the vagal control of the respiratory rhythm." @default.
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- W202202699 date "2001-01-01" @default.
- W202202699 modified "2023-09-26" @default.
- W202202699 title "Model of Nonassociative Learning in Vagal-Pontine Modulation of the Respiratory Rhythm" @default.
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- W202202699 doi "https://doi.org/10.1007/978-1-4615-1375-9_40" @default.
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