Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022028992> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2022028992 endingPage "34" @default.
- W2022028992 startingPage "26" @default.
- W2022028992 abstract "Recent identification of a second, inducible form of prostaglandin H synthase (PGHS-2) led to the hypothesis that constitutively expressed PGHS (PGHS-1) is involved in the homeostatic role of eicosanoids, whereas the inducible enzyme is responsible for their inflammatory actions. We report here the purification of PGHS-2 from near-term sheep placental cotyledons. The PGHS-2 from this tissue was purified in multimilligram quantities by a combination of anion-exchange, size-exclusion, and affinity chromatography. This enzyme is different from ovine seminal vesicle PGHS-1 and was characterized as PGHS-2 based on (a) chromatographic properties, (b) immunochemical reactivities with isoenzyme-specific antibodies, (c) amino acid microsequencing, (d) kinetics of reaction with arachidonic acid (Km= 2.1 ± 0.2 μMvs 8.3 ± 0.2 μMfor ovine PGHS-1), and (e) different sensitivities for several nonsteroidal antiinflammatory drugs. Since the first identification of PGHS, ram seminal vesicles served as a rich source of the enzyme (PGHS-1). Our studies establish the sheep placental cotyledons as a rich natural source of PGHS-2." @default.
- W2022028992 created "2016-06-24" @default.
- W2022028992 creator A5000655349 @default.
- W2022028992 creator A5018757311 @default.
- W2022028992 creator A5055682607 @default.
- W2022028992 creator A5063718775 @default.
- W2022028992 creator A5073163109 @default.
- W2022028992 date "1995-12-01" @default.
- W2022028992 modified "2023-10-16" @default.
- W2022028992 title "Purification and Characterization of Prostaglandin H Synthase-2 from Sheep Placental Cotyledons" @default.
- W2022028992 doi "https://doi.org/10.1006/abbi.1995.9934" @default.
- W2022028992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7503555" @default.
- W2022028992 hasPublicationYear "1995" @default.
- W2022028992 type Work @default.
- W2022028992 sameAs 2022028992 @default.
- W2022028992 citedByCount "116" @default.
- W2022028992 countsByYear W20220289922012 @default.
- W2022028992 countsByYear W20220289922013 @default.
- W2022028992 countsByYear W20220289922014 @default.
- W2022028992 countsByYear W20220289922015 @default.
- W2022028992 countsByYear W20220289922016 @default.
- W2022028992 countsByYear W20220289922017 @default.
- W2022028992 countsByYear W20220289922018 @default.
- W2022028992 countsByYear W20220289922020 @default.
- W2022028992 countsByYear W20220289922021 @default.
- W2022028992 countsByYear W20220289922023 @default.
- W2022028992 crossrefType "journal-article" @default.
- W2022028992 hasAuthorship W2022028992A5000655349 @default.
- W2022028992 hasAuthorship W2022028992A5018757311 @default.
- W2022028992 hasAuthorship W2022028992A5055682607 @default.
- W2022028992 hasAuthorship W2022028992A5063718775 @default.
- W2022028992 hasAuthorship W2022028992A5073163109 @default.
- W2022028992 hasConcept C119795356 @default.
- W2022028992 hasConcept C181199279 @default.
- W2022028992 hasConcept C185592680 @default.
- W2022028992 hasConcept C2778078955 @default.
- W2022028992 hasConcept C2780664492 @default.
- W2022028992 hasConcept C2780978440 @default.
- W2022028992 hasConcept C55493867 @default.
- W2022028992 hasConcept C86803240 @default.
- W2022028992 hasConceptScore W2022028992C119795356 @default.
- W2022028992 hasConceptScore W2022028992C181199279 @default.
- W2022028992 hasConceptScore W2022028992C185592680 @default.
- W2022028992 hasConceptScore W2022028992C2778078955 @default.
- W2022028992 hasConceptScore W2022028992C2780664492 @default.
- W2022028992 hasConceptScore W2022028992C2780978440 @default.
- W2022028992 hasConceptScore W2022028992C55493867 @default.
- W2022028992 hasConceptScore W2022028992C86803240 @default.
- W2022028992 hasIssue "1" @default.
- W2022028992 hasLocation W20220289921 @default.
- W2022028992 hasLocation W20220289922 @default.
- W2022028992 hasOpenAccess W2022028992 @default.
- W2022028992 hasPrimaryLocation W20220289921 @default.
- W2022028992 hasRelatedWork W196746948 @default.
- W2022028992 hasRelatedWork W2037443437 @default.
- W2022028992 hasRelatedWork W2050182051 @default.
- W2022028992 hasRelatedWork W2055657997 @default.
- W2022028992 hasRelatedWork W2060038873 @default.
- W2022028992 hasRelatedWork W2096037879 @default.
- W2022028992 hasRelatedWork W2318424018 @default.
- W2022028992 hasRelatedWork W4214595219 @default.
- W2022028992 hasRelatedWork W1933825081 @default.
- W2022028992 hasRelatedWork W2051285673 @default.
- W2022028992 hasVolume "324" @default.
- W2022028992 isParatext "false" @default.
- W2022028992 isRetracted "false" @default.
- W2022028992 magId "2022028992" @default.
- W2022028992 workType "article" @default.