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- W2022031287 startingPage "135" @default.
- W2022031287 abstract "The polo-like kinases (Plks) encompass a family of five serine/threonine protein kinases that play essential roles in many cellular processes involved in the control of the cell cycle, including entry into mitosis, DNA replication and the response to different types of stress. Plk1, which has been validated as a cancer target, came into the focus of many pharmaceutical companies for the development of small-molecule inhibitors as anticancer agents. Recently, FDA (Food and Drug Administration) has granted a breakthrough therapy designation to the Plk inhibitor BI 6727 (volasertib), which provided a survival benefit for patients suffering from acute myeloid leukemia. However, the various ATP-competitive inhibitors of Plk1 that are currently in clinical development also inhibit the activities of Plk2 and Plk3, which are considered as tumor suppressors. Plk3 contributes to the control and progression of the cell cycle while acting as a mediator of apoptosis and various types of cellular stress. The aberrant expression of Plk3 was found in different types of tumors. Recent progress has improved our understanding of Plk3 in regulating stress signaling and tumorigenesis. When using ATP-competitive Plk1 inhibitors, the biological roles of Plk1-related family members like Plk3 in cancer cells need to be considered carefully to improve treatment strategies against cancer." @default.
- W2022031287 created "2016-06-24" @default.
- W2022031287 creator A5019378375 @default.
- W2022031287 creator A5033962209 @default.
- W2022031287 creator A5072461589 @default.
- W2022031287 date "2015-04-27" @default.
- W2022031287 modified "2023-10-02" @default.
- W2022031287 title "The role of Plk3 in oncogenesis" @default.
- W2022031287 cites W1480741751 @default.
- W2022031287 cites W1491979926 @default.
- W2022031287 cites W1520947267 @default.
- W2022031287 cites W1537737236 @default.
- W2022031287 cites W1752089945 @default.
- W2022031287 cites W1784517069 @default.
- W2022031287 cites W1849061857 @default.
- W2022031287 cites W1869754668 @default.
- W2022031287 cites W1871272574 @default.
- W2022031287 cites W1924895133 @default.
- W2022031287 cites W1964588861 @default.
- W2022031287 cites W1966325621 @default.
- W2022031287 cites W1966841369 @default.
- W2022031287 cites W1968438075 @default.
- W2022031287 cites W1970720421 @default.
- W2022031287 cites W1970744454 @default.
- W2022031287 cites W1970972790 @default.
- W2022031287 cites W1971579914 @default.
- W2022031287 cites W1971936302 @default.
- W2022031287 cites W1975776530 @default.
- W2022031287 cites W1981172305 @default.
- W2022031287 cites W1986660515 @default.
- W2022031287 cites W1987453246 @default.
- W2022031287 cites W1991429659 @default.
- W2022031287 cites W1992683831 @default.
- W2022031287 cites W1992980968 @default.
- W2022031287 cites W1994219871 @default.
- W2022031287 cites W1994652412 @default.
- W2022031287 cites W1996588663 @default.
- W2022031287 cites W2001539882 @default.
- W2022031287 cites W2004981153 @default.
- W2022031287 cites W2006401070 @default.
- W2022031287 cites W2007914815 @default.
- W2022031287 cites W2011953594 @default.
- W2022031287 cites W2013824927 @default.
- W2022031287 cites W2014096417 @default.
- W2022031287 cites W2018046995 @default.
- W2022031287 cites W2018478612 @default.
- W2022031287 cites W2019023738 @default.
- W2022031287 cites W2019495949 @default.
- W2022031287 cites W2019701997 @default.
- W2022031287 cites W2020411912 @default.
- W2022031287 cites W2021469232 @default.
- W2022031287 cites W2022538460 @default.
- W2022031287 cites W2023796477 @default.
- W2022031287 cites W2025540821 @default.
- W2022031287 cites W2025685948 @default.
- W2022031287 cites W2028361915 @default.
- W2022031287 cites W2028825380 @default.
- W2022031287 cites W2029108033 @default.
- W2022031287 cites W2030486571 @default.
- W2022031287 cites W2030916234 @default.
- W2022031287 cites W2034269086 @default.
- W2022031287 cites W2036224418 @default.
- W2022031287 cites W2037874673 @default.
- W2022031287 cites W2038765347 @default.
- W2022031287 cites W2038951216 @default.
- W2022031287 cites W2038970224 @default.
- W2022031287 cites W2039291069 @default.
- W2022031287 cites W2040400275 @default.
- W2022031287 cites W2040825881 @default.
- W2022031287 cites W2041601152 @default.
- W2022031287 cites W2042146481 @default.
- W2022031287 cites W2048454522 @default.
- W2022031287 cites W2048551141 @default.
- W2022031287 cites W2050285373 @default.
- W2022031287 cites W2050368453 @default.
- W2022031287 cites W2051210198 @default.
- W2022031287 cites W2053738387 @default.
- W2022031287 cites W2053856024 @default.
- W2022031287 cites W2056050933 @default.
- W2022031287 cites W2059706603 @default.
- W2022031287 cites W2061646337 @default.
- W2022031287 cites W2065243832 @default.
- W2022031287 cites W2066219180 @default.
- W2022031287 cites W2068220878 @default.
- W2022031287 cites W2070985735 @default.
- W2022031287 cites W2071898856 @default.
- W2022031287 cites W2072992526 @default.
- W2022031287 cites W2075707444 @default.
- W2022031287 cites W2076183717 @default.
- W2022031287 cites W2077075729 @default.
- W2022031287 cites W2077813812 @default.
- W2022031287 cites W2079038433 @default.
- W2022031287 cites W2079481706 @default.
- W2022031287 cites W2079645368 @default.
- W2022031287 cites W2080672462 @default.
- W2022031287 cites W2080791584 @default.
- W2022031287 cites W2082087067 @default.
- W2022031287 cites W2083068695 @default.