FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022032351> ?p ?o ?g. }

• W2022032351 endingPage "247" @default.
• W2022032351 startingPage "239" @default.
• W2022032351 abstract "Agomelatine (S 20098) has a unique and new pharmacological profile. It is a melatoninergic agonist and selective antagonist of 5-HT2C receptors, and has been shown to be active in several animal models of depression. The aim of this study was to determine the active dose of agomelatine in the treatment of major depressive disorder (DSM-IV criteria). The methodology used was a conventional double-blind design comparing three different doses of agomelatine (1, 5 and 25 mg once a day) with placebo over an 8-week treatment period. Paroxetine was used as the study validator. Seven hundred and eleven patients with a baseline mean score of 27.4 on the 17-item Hamilton Rating Scale for Depression (HAM-D) were included. On the pivotal analysis, the mean final HAM-D total score (Full Analysis Set LOCF) demonstrated agomelatine 25 mg to be statistically more effective than placebo. This was confirmed by other analyses and criteria (responders, remission, subpopulation of severely depressed patients, Montgomery-Asberg Depression Rating Scale, Clinical Global Impression-Severity of Illness). Agomelatine 25 mg alleviated the anxiety associated with depression, as measured on Hamilton Anxiety Scale. Paroxetine was found to be effective on pivotal analysis and most of the secondary criteria used to validate the study methodology and population. Agomelatine, whatever the dose, showed good acceptability with a side-effects profile close to that of placebo. In conclusion, this study demonstrates that agomelatine is efficient in the treatment of major depressive disorder and that 25 mg is the target dose." @default.
• W2022032351 created "2016-06-24" @default.
• W2022032351 creator A5043538270 @default.
• W2022032351 creator A5087579683 @default.
• W2022032351 creator A5088019925 @default.
• W2022032351 date "2002-09-01" @default.
• W2022032351 modified "2023-10-16" @default.
• W2022032351 title "Determination of the dose of agomelatine, a melatoninergic agonist and selective 5-HT2C antagonist, in the treatment of major depressive disorder: a placebo-controlled dose range study" @default.
• W2022032351 cites W126168250 @default.
• W2022032351 cites W1965454331 @default.
• W2022032351 cites W1986437549 @default.
• W2022032351 cites W2002741313 @default.
• W2022032351 cites W2005021105 @default.
• W2022032351 cites W2010882652 @default.
• W2022032351 cites W2022191212 @default.
• W2022032351 cites W2043038606 @default.
• W2022032351 cites W2043046773 @default.
• W2022032351 cites W2050715406 @default.
• W2022032351 cites W2052487000 @default.
• W2022032351 cites W2056513437 @default.
• W2022032351 cites W2061378977 @default.
• W2022032351 cites W2061929866 @default.
• W2022032351 cites W2063129138 @default.
• W2022032351 cites W2065062277 @default.
• W2022032351 cites W2083991574 @default.
• W2022032351 cites W2089858686 @default.
• W2022032351 cites W2091470293 @default.
• W2022032351 cites W2094918976 @default.
• W2022032351 cites W2131823335 @default.
• W2022032351 cites W2160070901 @default.
• W2022032351 cites W2317324607 @default.
• W2022032351 cites W2327546923 @default.
• W2022032351 cites W2332470233 @default.
• W2022032351 cites W4244103373 @default.
• W2022032351 doi "https://doi.org/10.1097/00004850-200209000-00004" @default.
• W2022032351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12177586" @default.
• W2022032351 hasPublicationYear "2002" @default.
• W2022032351 type Work @default.
• W2022032351 sameAs 2022032351 @default.
• W2022032351 citedByCount "337" @default.
• W2022032351 countsByYear W20220323512012 @default.
• W2022032351 countsByYear W20220323512013 @default.
• W2022032351 countsByYear W20220323512014 @default.
• W2022032351 countsByYear W20220323512015 @default.
• W2022032351 countsByYear W20220323512016 @default.
• W2022032351 countsByYear W20220323512017 @default.
• W2022032351 countsByYear W20220323512018 @default.
• W2022032351 countsByYear W20220323512019 @default.
• W2022032351 countsByYear W20220323512020 @default.
• W2022032351 countsByYear W20220323512021 @default.
• W2022032351 countsByYear W20220323512022 @default.
• W2022032351 countsByYear W20220323512023 @default.
• W2022032351 crossrefType "journal-article" @default.
• W2022032351 hasAuthorship W2022032351A5043538270 @default.
• W2022032351 hasAuthorship W2022032351A5087579683 @default.
• W2022032351 hasAuthorship W2022032351A5088019925 @default.
• W2022032351 hasConcept C118552586 @default.
• W2022032351 hasConcept C126322002 @default.
• W2022032351 hasConcept C142724271 @default.
• W2022032351 hasConcept C15744967 @default.
• W2022032351 hasConcept C170493617 @default.
• W2022032351 hasConcept C204787440 @default.
• W2022032351 hasConcept C27081682 @default.
• W2022032351 hasConcept C2776000289 @default.
• W2022032351 hasConcept C2776466505 @default.
• W2022032351 hasConcept C2777696351 @default.
• W2022032351 hasConcept C2777828372 @default.
• W2022032351 hasConcept C2778938600 @default.
• W2022032351 hasConcept C2779177272 @default.
• W2022032351 hasConcept C2780051608 @default.
• W2022032351 hasConcept C2780733359 @default.
• W2022032351 hasConcept C2780798758 @default.
• W2022032351 hasConcept C2908647359 @default.
• W2022032351 hasConcept C558461103 @default.
• W2022032351 hasConcept C58732023 @default.
• W2022032351 hasConcept C71924100 @default.
• W2022032351 hasConcept C99454951 @default.
• W2022032351 hasConceptScore W2022032351C118552586 @default.
• W2022032351 hasConceptScore W2022032351C126322002 @default.
• W2022032351 hasConceptScore W2022032351C142724271 @default.
• W2022032351 hasConceptScore W2022032351C15744967 @default.
• W2022032351 hasConceptScore W2022032351C170493617 @default.
• W2022032351 hasConceptScore W2022032351C204787440 @default.
• W2022032351 hasConceptScore W2022032351C27081682 @default.
• W2022032351 hasConceptScore W2022032351C2776000289 @default.
• W2022032351 hasConceptScore W2022032351C2776466505 @default.
• W2022032351 hasConceptScore W2022032351C2777696351 @default.
• W2022032351 hasConceptScore W2022032351C2777828372 @default.
• W2022032351 hasConceptScore W2022032351C2778938600 @default.
• W2022032351 hasConceptScore W2022032351C2779177272 @default.
• W2022032351 hasConceptScore W2022032351C2780051608 @default.
• W2022032351 hasConceptScore W2022032351C2780733359 @default.
• W2022032351 hasConceptScore W2022032351C2780798758 @default.
• W2022032351 hasConceptScore W2022032351C2908647359 @default.
• W2022032351 hasConceptScore W2022032351C558461103 @default.
• W2022032351 hasConceptScore W2022032351C58732023 @default.
• W2022032351 hasConceptScore W2022032351C71924100 @default.
• W2022032351 hasConceptScore W2022032351C99454951 @default.

• next