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• W2022033428 startingPage "3201" @default.
• W2022033428 abstract "SUMMARY During severe arterial hypoxia leading to brain anoxia, most mammalian neurons undergo a massive depolarisation terminating in cell death. However,some neurons of the adult brain and most immature nervous structures tolerate extended periods of hypoxia–anoxia. An understanding of the mechanisms underlying this tolerance to oxygen depletion is pivotal for developing strategies to protect the brain from consequences of hypoxic-ischemic insults. ATP-sensitive K+ (KATP) channels are good subjects for this study as they are activated by processes associated with energy deprivation and can counteract the terminal anoxic-ischemic neuronal depolarisation. This review summarises in vitro analyses on the role of KATP channels in hypoxia–anoxia in three distinct neuronal systems of rodents. In dorsal vagal neurons, blockade of KATPchannels with sulfonylureas abolishes the hypoxic-anoxic hyperpolarisation. However, this does not affect the extreme tolerance of these neurons to oxygen depletion as evidenced by a moderate and sustained increase of intracellular Ca2+ (Cai). By contrast, a sulfonylurea-induced block of KATP channels shortens the delay of occurrence of a major Cai rise in cerebellar Purkinje neurons. In neurons of the neonatal medullary respiratory network, KATP channel blockers reverse the anoxic hyperpolarisation associated with slowing of respiratory frequency. This may constitute an adaptive mechanism for energy preservation. These studies demonstrate that KATP channels are an ubiquituous feature of mammalian neurons and may, indeed, play a protective role in brain hypoxia." @default.
• W2022033428 created "2016-06-24" @default.
• W2022033428 creator A5084176336 @default.
• W2022033428 date "2004-08-15" @default.
• W2022033428 modified "2023-10-15" @default.
• W2022033428 title "Protective role of neuronal KATP channels in brain hypoxia" @default.
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• W2022033428 cites W1487837909 @default.
• W2022033428 cites W1558119278 @default.
• W2022033428 cites W1964337652 @default.
• W2022033428 cites W1966034584 @default.
• W2022033428 cites W1973052482 @default.
• W2022033428 cites W1977806402 @default.
• W2022033428 cites W1982395498 @default.
• W2022033428 cites W1982892406 @default.
• W2022033428 cites W1994688027 @default.
• W2022033428 cites W1995957068 @default.
• W2022033428 cites W1996243499 @default.
• W2022033428 cites W1997041986 @default.
• W2022033428 cites W1998217227 @default.
• W2022033428 cites W1999140000 @default.
• W2022033428 cites W2004976934 @default.
• W2022033428 cites W2008235109 @default.
• W2022033428 cites W2012813389 @default.
• W2022033428 cites W2017491447 @default.
• W2022033428 cites W2020675852 @default.
• W2022033428 cites W2022464897 @default.
• W2022033428 cites W2023140801 @default.
• W2022033428 cites W2024794798 @default.
• W2022033428 cites W2025821901 @default.
• W2022033428 cites W2029247375 @default.
• W2022033428 cites W2036613870 @default.
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• W2022033428 cites W2037688283 @default.
• W2022033428 cites W2039213160 @default.
• W2022033428 cites W2040809342 @default.
• W2022033428 cites W2042251982 @default.
• W2022033428 cites W2044908388 @default.
• W2022033428 cites W2048734958 @default.
• W2022033428 cites W2051604675 @default.
• W2022033428 cites W2051915518 @default.
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• W2022033428 cites W2063571324 @default.
• W2022033428 cites W2064688638 @default.
• W2022033428 cites W2066650398 @default.
• W2022033428 cites W2067039239 @default.
• W2022033428 cites W2067536822 @default.
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• W2022033428 doi "https://doi.org/10.1242/jeb.01106" @default.
• W2022033428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15299041" @default.
• W2022033428 hasPublicationYear "2004" @default.
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