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- W2022034114 abstract "Intracellular deoxyribosyl compounds were measured collectively and individually in vitamin B 12 -deficient Lactobacillus leichmannii , wherein DNA synthesis is impaired by defective deoxyribonucleotide synthesis, and in folate-deficient L. leichmannii and L. casei and thymine-deficient Escherichia coli 15 T − , wherein DNA synthesis is impaired by lack of thymidylate. Effects of the two types of deficiencies differed strikingly. Pool sizes were decreased by vitamin B 12 deficiency and increased by deficiencies of folic acid or thymine. All major deoxyribosyl compounds were uniformly decreased in vitamin B 12 deficiency, levels rising again after repletion. A number of deoxyribosyl compounds increased in folate and thymine deficiency, although responses of individual compounds differed in folate-limited L. leichmannii and thymine-limited E. coli 15 T − . Preliminary attempts to demonstrate accumulations of deoxyribosyl derivatives in folate-deficient humans and chicks were unsuccessful. A dTDP derivative, tentatively identified as a sugar complex, is the major intracellular deoxyribosyl compound in optimally nourished L. leichmannii . In folate deficiency, other intracellular thymine compounds disappear, but the dTDP derivative accumulates. A similar phenomenon was not observed in thymine-limited E. coli 15 T − . The results suggest that (1) vitamin B 12 participates in deoxyribosyl synthesis; (2) folate deficiency in the organisms studied is the equivalent of thymine deficiency; (3) a thymine derivative, probably dTTP, governs the repressor system controlling ribonucleotide reductase synthesis; and (4) the level of a major thymine derivative is controlled by factors other than those controlling the levels of the immediate DNA precursors." @default.
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- W2022034114 date "1966-11-01" @default.
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- W2022034114 title "Variations of intracellular deoxyribosyl compounds in deficiencies of vitamin B12, folic acid and thymine" @default.
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- W2022034114 doi "https://doi.org/10.1016/0005-2787(66)90376-5" @default.
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