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- W2022035527 endingPage "89" @default.
- W2022035527 startingPage "75" @default.
- W2022035527 abstract "Abstract Among the multiple and apparently unrelated effects of glucocorticoid hormones one of the best documented at the cellular level is the increased activity of specific enzymes. An experimental model of the latter effect is the induction of tyrosine aminotransferase in cultured hepatoma cells. A review of recent studies on the early steps of glucocorticoid action in this system leads to the proposition of the following mechanism. Glucocorticoids freely enter the cell and bind reversibly to intracellular receptors. These receptors are regulatory proteins which, upon association with certain steroids, undergo a conformational change that determines their interaction with nuclear chromatin. As a result, gene transcription is altered in such a way that the synthesis of specific enzymes is increased. Data from the literature suggest that these receptors could also be involved in other glucocorticoid effects on cell metabolism. A unitary hypothesis is discussed according to which the primary action of glucocorticoids consists in inhibiting cell growth while allowing the concomitant expression of specific enzymes." @default.
- W2022035527 created "2016-06-24" @default.
- W2022035527 creator A5083771400 @default.
- W2022035527 date "1975-01-01" @default.
- W2022035527 modified "2023-10-14" @default.
- W2022035527 title "Interaction of steroids with hepatoma cells: Molecular mechanisms of glucocorticoid hormone action" @default.
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