FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022035642> ?p ?o ?g. }

• W2022035642 endingPage "527" @default.
• W2022035642 startingPage "519" @default.
• W2022035642 abstract "Twenty-four adult Beechey ground squirrels persistently infected with the hepatitis B virus-related ground squirrel hepatitis virus (GSHV) remained infected with high levels of viral surface antigen (GSHsAg) and virion-associated DNA polymerase activity in the blood for over 2 years in captivity. Unlike humans infected with hepatitis B virus, no GSHsAg-bearing ground squirrels had surface antigen in the blood without DNA polymerase-containing virions, and the levels of these did not change. Only a very mild hepatitis was observed histologically in some of the virus-infected animals, with faint Shikata-staining detectable in some. Other animals exhibited no histologic evidence of hepatitis. While the closely related woodchuck hepatitis virus has been associated with more severe chronic hepatitis and a high incidence of liver cancer in woodchucks, these were not found in GSHV-infected ground squirrels when a similar number of animals were followed for a similar time of observation. Experimental infection of ground squirrels with no evidence of current or past GSHV infection resulted in three types of response: (i) self-limited or transient GSHV-positive infection; (ii) GSHV-positive infection which became persistent, and (iii) primary anti-GSHs and anti-GSHc (antibody to the viral core antigen) responses without detectable GSHsAg or virion DNA polymerase activity in the blood. These responses are similar to those observed following experimental infection of man with HBV. GSHV produced none of the three responses when injected into a variety of laboratory animal species and a chimpanzee, causing only an antibody response to GSHsAg. No evidence of current or past infection was detected in a number of animal species from an area endemic for GSHV. The virus has only been found in one area of northern California, with a carrier rate in that location reaching 52%." @default.
• W2022035642 created "2016-06-24" @default.
• W2022035642 creator A5001866590 @default.
• W2022035642 creator A5042206741 @default.
• W2022035642 creator A5043224844 @default.
• W2022035642 creator A5052341039 @default.
• W2022035642 creator A5079100505 @default.
• W2022035642 date "2007-09-21" @default.
• W2022035642 modified "2023-09-26" @default.
• W2022035642 title "Ground Squirrel Hepatitis Virus Infection" @default.
• W2022035642 cites W1492449073 @default.
• W2022035642 cites W1509762867 @default.
• W2022035642 cites W1519323803 @default.
• W2022035642 cites W1590447281 @default.
• W2022035642 cites W1796250533 @default.
• W2022035642 cites W1814828787 @default.
• W2022035642 cites W1864161809 @default.
• W2022035642 cites W1972835903 @default.
• W2022035642 cites W1989546700 @default.
• W2022035642 cites W2000784549 @default.
• W2022035642 cites W2017767695 @default.
• W2022035642 cites W2056271541 @default.
• W2022035642 cites W2096808350 @default.
• W2022035642 cites W2107375267 @default.
• W2022035642 cites W2114836143 @default.
• W2022035642 cites W2122305232 @default.
• W2022035642 cites W2144266248 @default.
• W2022035642 doi "https://doi.org/10.1002/hep.1840030408" @default.
• W2022035642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6862363" @default.
• W2022035642 hasPublicationYear "2007" @default.
• W2022035642 type Work @default.
• W2022035642 sameAs 2022035642 @default.
• W2022035642 citedByCount "44" @default.
• W2022035642 countsByYear W20220356422015 @default.
• W2022035642 countsByYear W20220356422020 @default.
• W2022035642 crossrefType "journal-article" @default.
• W2022035642 hasAuthorship W2022035642A5001866590 @default.
• W2022035642 hasAuthorship W2022035642A5042206741 @default.
• W2022035642 hasAuthorship W2022035642A5043224844 @default.
• W2022035642 hasAuthorship W2022035642A5052341039 @default.
• W2022035642 hasAuthorship W2022035642A5079100505 @default.
• W2022035642 hasConcept C105702510 @default.
• W2022035642 hasConcept C159047783 @default.
• W2022035642 hasConcept C2522874641 @default.
• W2022035642 hasConcept C2776030879 @default.
• W2022035642 hasConcept C2780588931 @default.
• W2022035642 hasConcept C3019983190 @default.
• W2022035642 hasConcept C3020804797 @default.
• W2022035642 hasConcept C71924100 @default.
• W2022035642 hasConceptScore W2022035642C105702510 @default.
• W2022035642 hasConceptScore W2022035642C159047783 @default.
• W2022035642 hasConceptScore W2022035642C2522874641 @default.
• W2022035642 hasConceptScore W2022035642C2776030879 @default.
• W2022035642 hasConceptScore W2022035642C2780588931 @default.
• W2022035642 hasConceptScore W2022035642C3019983190 @default.
• W2022035642 hasConceptScore W2022035642C3020804797 @default.
• W2022035642 hasConceptScore W2022035642C71924100 @default.
• W2022035642 hasIssue "4" @default.
• W2022035642 hasLocation W20220356421 @default.
• W2022035642 hasLocation W20220356422 @default.
• W2022035642 hasOpenAccess W2022035642 @default.
• W2022035642 hasPrimaryLocation W20220356421 @default.
• W2022035642 hasRelatedWork W1831792663 @default.
• W2022035642 hasRelatedWork W1976354249 @default.
• W2022035642 hasRelatedWork W2010455632 @default.
• W2022035642 hasRelatedWork W2616614960 @default.
• W2022035642 hasRelatedWork W2623132315 @default.
• W2022035642 hasRelatedWork W2883373999 @default.
• W2022035642 hasRelatedWork W4232551373 @default.
• W2022035642 hasRelatedWork W4233452847 @default.
• W2022035642 hasRelatedWork W4236089917 @default.
• W2022035642 hasRelatedWork W4301694837 @default.
• W2022035642 hasVolume "3" @default.
• W2022035642 isParatext "false" @default.
• W2022035642 isRetracted "false" @default.
• W2022035642 magId "2022035642" @default.
• W2022035642 workType "article" @default.