FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022038140> ?p ?o ?g. }

• W2022038140 endingPage "893" @default.
• W2022038140 startingPage "886" @default.
• W2022038140 abstract "Whereas most septic patients have an underlying comorbidity, most animal models of sepsis use mice that were healthy before the onset of infection. Malignancy is the most common comorbidity associated with sepsis. The purpose of this study was to determine whether mice with cancer have a different response to sepsis than healthy animals.Prospective, randomized controlled study.Animal laboratory in a university medical center.C57Bl/6 mice.Animals received a subcutaneous injection of either 250,000 cells of the transplantable pancreatic adenocarcinoma cell line Pan02 (cancer) or phosphate-buffered saline (healthy). Three weeks later, mice given Pan02 cells had reproducible, nonmetastatic tumors. Both groups of mice then underwent intratracheal injection of either Pseudomonas aeruginosa (septic) or 0.9% NaCl (sham). Animals were killed 24 hrs postoperatively or followed-up 7 days for survival.Mice with cancer and healthy mice appeared similar when subjected to sham operation, although cancer animals had lower levels of T- and B-lymphocyte apoptosis. Septic mice with cancer had increased mortality compared to previously healthy septic mice subjected to the identical injury (52% vs. 28%; p = .04). This was associated with increased bacteremia but no difference in local pulmonary infection. Septic mice with cancer also had increased intestinal epithelial apoptosis. Although sepsis induced an increase in T- and B-lymphocyte apoptosis in all animals, septic mice with cancer had decreased T- and B-lymphocyte apoptosis compared to previously healthy septic mice. Serum and pulmonary cytokines, lung histology, complete blood counts, and intestinal proliferation were similar between septic mice with cancer and previously healthy septic mice.When subjected to the same septic insult, mice with cancer have increased mortality compared to previously healthy animals. Decreased systemic bacterial clearance and alterations in intestinal epithelial and lymphocyte apoptosis may help explain this differential response." @default.
• W2022038140 created "2016-06-24" @default.
• W2022038140 creator A5001543982 @default.
• W2022038140 creator A5001569412 @default.
• W2022038140 creator A5010704199 @default.
• W2022038140 creator A5012355242 @default.
• W2022038140 creator A5012550644 @default.
• W2022038140 creator A5023090393 @default.
• W2022038140 creator A5032854284 @default.
• W2022038140 creator A5041058044 @default.
• W2022038140 creator A5073143289 @default.
• W2022038140 creator A5074460989 @default.
• W2022038140 creator A5083669330 @default.
• W2022038140 creator A5084298635 @default.
• W2022038140 creator A5085436368 @default.
• W2022038140 date "2010-03-01" @default.
• W2022038140 modified "2023-09-26" @default.
• W2022038140 title "Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis*" @default.
• W2022038140 cites W1545509462 @default.
• W2022038140 cites W1661840774 @default.
• W2022038140 cites W1967635792 @default.
• W2022038140 cites W1972350167 @default.
• W2022038140 cites W1975763557 @default.
• W2022038140 cites W1976738774 @default.
• W2022038140 cites W1980661081 @default.
• W2022038140 cites W1985956263 @default.
• W2022038140 cites W1993065921 @default.
• W2022038140 cites W2010624167 @default.
• W2022038140 cites W2016541749 @default.
• W2022038140 cites W2036850094 @default.
• W2022038140 cites W2049927822 @default.
• W2022038140 cites W2052303540 @default.
• W2022038140 cites W2053554593 @default.
• W2022038140 cites W2059061787 @default.
• W2022038140 cites W2063982677 @default.
• W2022038140 cites W2065520737 @default.
• W2022038140 cites W2069869279 @default.
• W2022038140 cites W2070743921 @default.
• W2022038140 cites W2071693928 @default.
• W2022038140 cites W2072439886 @default.
• W2022038140 cites W2077657053 @default.
• W2022038140 cites W2094265468 @default.
• W2022038140 cites W2125498567 @default.
• W2022038140 cites W2127860293 @default.
• W2022038140 cites W2146007259 @default.
• W2022038140 cites W2156900485 @default.
• W2022038140 cites W2165823492 @default.
• W2022038140 cites W2166504245 @default.
• W2022038140 cites W2320098151 @default.
• W2022038140 cites W4313343369 @default.
• W2022038140 doi "https://doi.org/10.1097/ccm.0b013e3181c8fdb1" @default.
• W2022038140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2825291" @default.
• W2022038140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20009755" @default.
• W2022038140 hasPublicationYear "2010" @default.
• W2022038140 type Work @default.
• W2022038140 sameAs 2022038140 @default.
• W2022038140 citedByCount "47" @default.
• W2022038140 countsByYear W20220381402012 @default.
• W2022038140 countsByYear W20220381402013 @default.
• W2022038140 countsByYear W20220381402014 @default.
• W2022038140 countsByYear W20220381402015 @default.
• W2022038140 countsByYear W20220381402016 @default.
• W2022038140 countsByYear W20220381402017 @default.
• W2022038140 countsByYear W20220381402018 @default.
• W2022038140 countsByYear W20220381402019 @default.
• W2022038140 countsByYear W20220381402020 @default.
• W2022038140 countsByYear W20220381402021 @default.
• W2022038140 countsByYear W20220381402022 @default.
• W2022038140 countsByYear W20220381402023 @default.
• W2022038140 crossrefType "journal-article" @default.
• W2022038140 hasAuthorship W2022038140A5001543982 @default.
• W2022038140 hasAuthorship W2022038140A5001569412 @default.
• W2022038140 hasAuthorship W2022038140A5010704199 @default.
• W2022038140 hasAuthorship W2022038140A5012355242 @default.
• W2022038140 hasAuthorship W2022038140A5012550644 @default.
• W2022038140 hasAuthorship W2022038140A5023090393 @default.
• W2022038140 hasAuthorship W2022038140A5032854284 @default.
• W2022038140 hasAuthorship W2022038140A5041058044 @default.
• W2022038140 hasAuthorship W2022038140A5073143289 @default.
• W2022038140 hasAuthorship W2022038140A5074460989 @default.
• W2022038140 hasAuthorship W2022038140A5083669330 @default.
• W2022038140 hasAuthorship W2022038140A5084298635 @default.
• W2022038140 hasAuthorship W2022038140A5085436368 @default.
• W2022038140 hasBestOaLocation W20220381402 @default.
• W2022038140 hasConcept C121608353 @default.
• W2022038140 hasConcept C126322002 @default.
• W2022038140 hasConcept C190283241 @default.
• W2022038140 hasConcept C203014093 @default.
• W2022038140 hasConcept C2776256026 @default.
• W2022038140 hasConcept C2777628635 @default.
• W2022038140 hasConcept C2778384902 @default.
• W2022038140 hasConcept C2779443120 @default.
• W2022038140 hasConcept C501593827 @default.
• W2022038140 hasConcept C55493867 @default.
• W2022038140 hasConcept C71924100 @default.
• W2022038140 hasConcept C86803240 @default.
• W2022038140 hasConcept C89423630 @default.
• W2022038140 hasConcept C90924648 @default.

• next