Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022038512> ?p ?o ?g. }
- W2022038512 endingPage "281" @default.
- W2022038512 startingPage "278" @default.
- W2022038512 abstract "Induced pluripotent stem cell (iPSC) technology has emerged as the most promising method for generating patient-specific human embryonic stem (ES) cells and adult stem cells (Takahashi et al., 2007, Cell 131:861-872; Wernig et al., 2007, Nature 448:318-324; Park et al., 2008, Nature 451:141-146). So far, most studies of direct reprogramming have been done by using lentiviruses/retroviruses encoding the reprogramming factors. This represents a major limitation to therapeutic applications since viral integration in the host genome increases the risk of tumorigenicity, and low-level residual expression of reprogramming factors may alter the differentiation potential of the human iPSCs (hiPSCs). As a result, more attention has been paid to developing new techniques to manipulate the human genome, with the goal of making safer hiPSCs that have fewer or no lesions or alterations in the genome. Additionally, the efficiency of reprogramming and of homologous recombination in gene therapy must be improved, if iPSC technology is to be a viable tool in regenerative medicine. Here, we summarize the recent developments in human genome manipulation for generating hiPSCs and advances in homologous recombination for gene targeting." @default.
- W2022038512 created "2016-06-24" @default.
- W2022038512 creator A5006525921 @default.
- W2022038512 creator A5019075752 @default.
- W2022038512 creator A5043322110 @default.
- W2022038512 date "2010-02-01" @default.
- W2022038512 modified "2023-10-18" @default.
- W2022038512 title "Genome modification in human embryonic stem cells" @default.
- W2022038512 cites W1804821915 @default.
- W2022038512 cites W1967999689 @default.
- W2022038512 cites W1968140045 @default.
- W2022038512 cites W1977442228 @default.
- W2022038512 cites W1980449150 @default.
- W2022038512 cites W1988865085 @default.
- W2022038512 cites W1993834457 @default.
- W2022038512 cites W2002179012 @default.
- W2022038512 cites W2004360848 @default.
- W2022038512 cites W2009761723 @default.
- W2022038512 cites W2010031978 @default.
- W2022038512 cites W2014416902 @default.
- W2022038512 cites W2020466762 @default.
- W2022038512 cites W2021581968 @default.
- W2022038512 cites W2025946320 @default.
- W2022038512 cites W2027296526 @default.
- W2022038512 cites W2029506701 @default.
- W2022038512 cites W2032570745 @default.
- W2022038512 cites W2045618741 @default.
- W2022038512 cites W2048273322 @default.
- W2022038512 cites W2050689355 @default.
- W2022038512 cites W2051395442 @default.
- W2022038512 cites W2053576250 @default.
- W2022038512 cites W2071933708 @default.
- W2022038512 cites W2072239613 @default.
- W2022038512 cites W2079695054 @default.
- W2022038512 cites W2081777956 @default.
- W2022038512 cites W2084869091 @default.
- W2022038512 cites W2086046223 @default.
- W2022038512 cites W2086943348 @default.
- W2022038512 cites W2088101102 @default.
- W2022038512 cites W2094979867 @default.
- W2022038512 cites W2103540918 @default.
- W2022038512 cites W2106485710 @default.
- W2022038512 cites W2123784922 @default.
- W2022038512 cites W2125987139 @default.
- W2022038512 cites W2126237980 @default.
- W2022038512 cites W2132256310 @default.
- W2022038512 cites W2133501984 @default.
- W2022038512 cites W2138977668 @default.
- W2022038512 cites W2142046859 @default.
- W2022038512 cites W2158979552 @default.
- W2022038512 cites W2164470499 @default.
- W2022038512 cites W2164618384 @default.
- W2022038512 cites W2167845957 @default.
- W2022038512 doi "https://doi.org/10.1002/jcp.21948" @default.
- W2022038512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19877154" @default.
- W2022038512 hasPublicationYear "2010" @default.
- W2022038512 type Work @default.
- W2022038512 sameAs 2022038512 @default.
- W2022038512 citedByCount "37" @default.
- W2022038512 countsByYear W20220385122012 @default.
- W2022038512 countsByYear W20220385122013 @default.
- W2022038512 countsByYear W20220385122014 @default.
- W2022038512 countsByYear W20220385122016 @default.
- W2022038512 countsByYear W20220385122017 @default.
- W2022038512 countsByYear W20220385122018 @default.
- W2022038512 countsByYear W20220385122020 @default.
- W2022038512 countsByYear W20220385122021 @default.
- W2022038512 crossrefType "journal-article" @default.
- W2022038512 hasAuthorship W2022038512A5006525921 @default.
- W2022038512 hasAuthorship W2022038512A5019075752 @default.
- W2022038512 hasAuthorship W2022038512A5043322110 @default.
- W2022038512 hasConcept C102744134 @default.
- W2022038512 hasConcept C104317684 @default.
- W2022038512 hasConcept C107459253 @default.
- W2022038512 hasConcept C10854531 @default.
- W2022038512 hasConcept C141231307 @default.
- W2022038512 hasConcept C144501496 @default.
- W2022038512 hasConcept C145103041 @default.
- W2022038512 hasConcept C28328180 @default.
- W2022038512 hasConcept C2910924664 @default.
- W2022038512 hasConcept C54355233 @default.
- W2022038512 hasConcept C70721500 @default.
- W2022038512 hasConcept C77255625 @default.
- W2022038512 hasConcept C86803240 @default.
- W2022038512 hasConcept C95444343 @default.
- W2022038512 hasConceptScore W2022038512C102744134 @default.
- W2022038512 hasConceptScore W2022038512C104317684 @default.
- W2022038512 hasConceptScore W2022038512C107459253 @default.
- W2022038512 hasConceptScore W2022038512C10854531 @default.
- W2022038512 hasConceptScore W2022038512C141231307 @default.
- W2022038512 hasConceptScore W2022038512C144501496 @default.
- W2022038512 hasConceptScore W2022038512C145103041 @default.
- W2022038512 hasConceptScore W2022038512C28328180 @default.
- W2022038512 hasConceptScore W2022038512C2910924664 @default.
- W2022038512 hasConceptScore W2022038512C54355233 @default.
- W2022038512 hasConceptScore W2022038512C70721500 @default.
- W2022038512 hasConceptScore W2022038512C77255625 @default.
- W2022038512 hasConceptScore W2022038512C86803240 @default.