FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022039428> ?p ?o ?g. }

• W2022039428 endingPage "406" @default.
• W2022039428 startingPage "399" @default.
• W2022039428 abstract "Ropivacaine has an optimal toxicity profile for epidural anesthesia in adults, but there are currently no studies concerning its pharmacokinetics during continuous infusion. The primary objective of this study was to evaluate the pharmacokinetics and safety of ropivacaine in adults during a 48-h continuous epidural infusion. We enrolled 43 adults (ASA I-II) scheduled for major abdominal or urologic surgery with postoperative continuous epidural analgesia with ropivacaine 0.2% (5 mL/h) and sufentanil 0.75 μg/mL for 48 h. Ropivacaine blood samples were collected during continuous epidural infusion before the bolus and 3, 6, 12, 24, 48, 54, 60 h after the bolus; plasma concentrations were measured on HPLC-UV. The concentration-time relationship of ropivacaine levels was analyzed using a population pharmacokinetic method based on a mixed-effect-model approach (P-PHARM software). Mean plasma concentration of ropivacaine at the end of epidural infusion (C48h) was 1.69 μg/mL (0.21–3.8 μg/mL). Mean (range) Cmax was 1.82 μg/mL (0.61–4.0 μg/mL); the area under the plasma concentration curve, AUC (0-60), was 67.48 ± 30.60 μg·h/mL. Total plasma ropivacaine concentrations fell mainly within (84%) or below (12%) the range reported to be safe in adults (1.0–3.0 μg/mL). Only two patients (5%) reached ropivacaine plasma levels higher than 3 μg/mL, namely 3.8 and 4.0 μg/mL at 48 and 54 h, respectively. Total ropivacaine concentrations up to 4.0 μg/mL were tolerated during long-term epidural ropivacaine infusion. Mean clearance for total ropivacaine was 5.33 L/h. Age was the only covariable to significantly reduce clearance variability: CL (L/h) = 15.04 − 0.148 × age (years). The volume of distribution (Vd) was 92.15 L. The infusion dosing period half-life (t1/2,DP = 0.693 × Vd/CL) was 10.8 h. Exposure to ropivacaine during epidural infusion is highly variable. The apparent infusion dosing half-life t1/2,DP is the most appropriate parameter to predict drug accumulation upon epidural infusion since it appears to better reflect the interplay interference between volume distribution and absorption rate during the accumulation phase. Prediction of ropivacaine accumulation can be improved by considering patient age." @default.
• W2022039428 created "2016-06-24" @default.
• W2022039428 creator A5006736621 @default.
• W2022039428 creator A5006961368 @default.
• W2022039428 creator A5044885843 @default.
• W2022039428 creator A5051593396 @default.
• W2022039428 creator A5059670970 @default.
• W2022039428 creator A5090116152 @default.
• W2022039428 creator A5091226902 @default.
• W2022039428 date "2010-11-16" @default.
• W2022039428 modified "2023-10-14" @default.
• W2022039428 title "Flip-flop kinetics of ropivacaine during continuous epidural infusion influences its accumulation rate" @default.
• W2022039428 cites W1964958875 @default.
• W2022039428 cites W1968887929 @default.
• W2022039428 cites W1970782812 @default.
• W2022039428 cites W1982455413 @default.
• W2022039428 cites W1990093871 @default.
• W2022039428 cites W1990380657 @default.
• W2022039428 cites W1996777303 @default.
• W2022039428 cites W1996828009 @default.
• W2022039428 cites W2023479055 @default.
• W2022039428 cites W2043996867 @default.
• W2022039428 cites W2044487865 @default.
• W2022039428 cites W2063482065 @default.
• W2022039428 cites W2075695311 @default.
• W2022039428 cites W2080425496 @default.
• W2022039428 cites W2091694453 @default.
• W2022039428 cites W2098960917 @default.
• W2022039428 cites W2106083804 @default.
• W2022039428 cites W2106653777 @default.
• W2022039428 cites W2131671972 @default.
• W2022039428 cites W2330068990 @default.
• W2022039428 doi "https://doi.org/10.1007/s00228-010-0927-x" @default.
• W2022039428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21079936" @default.
• W2022039428 hasPublicationYear "2010" @default.
• W2022039428 type Work @default.
• W2022039428 sameAs 2022039428 @default.
• W2022039428 citedByCount "20" @default.
• W2022039428 countsByYear W20220394282013 @default.
• W2022039428 countsByYear W20220394282014 @default.
• W2022039428 countsByYear W20220394282015 @default.
• W2022039428 countsByYear W20220394282016 @default.
• W2022039428 countsByYear W20220394282017 @default.
• W2022039428 countsByYear W20220394282018 @default.
• W2022039428 countsByYear W20220394282019 @default.
• W2022039428 countsByYear W20220394282020 @default.
• W2022039428 countsByYear W20220394282021 @default.
• W2022039428 countsByYear W20220394282023 @default.
• W2022039428 crossrefType "journal-article" @default.
• W2022039428 hasAuthorship W2022039428A5006736621 @default.
• W2022039428 hasAuthorship W2022039428A5006961368 @default.
• W2022039428 hasAuthorship W2022039428A5044885843 @default.
• W2022039428 hasAuthorship W2022039428A5051593396 @default.
• W2022039428 hasAuthorship W2022039428A5059670970 @default.
• W2022039428 hasAuthorship W2022039428A5090116152 @default.
• W2022039428 hasAuthorship W2022039428A5091226902 @default.
• W2022039428 hasBestOaLocation W20220394282 @default.
• W2022039428 hasConcept C112705442 @default.
• W2022039428 hasConcept C141071460 @default.
• W2022039428 hasConcept C22979827 @default.
• W2022039428 hasConcept C2777019824 @default.
• W2022039428 hasConcept C2780269707 @default.
• W2022039428 hasConcept C42219234 @default.
• W2022039428 hasConcept C43376680 @default.
• W2022039428 hasConcept C71924100 @default.
• W2022039428 hasConcept C98274493 @default.
• W2022039428 hasConceptScore W2022039428C112705442 @default.
• W2022039428 hasConceptScore W2022039428C141071460 @default.
• W2022039428 hasConceptScore W2022039428C22979827 @default.
• W2022039428 hasConceptScore W2022039428C2777019824 @default.
• W2022039428 hasConceptScore W2022039428C2780269707 @default.
• W2022039428 hasConceptScore W2022039428C42219234 @default.
• W2022039428 hasConceptScore W2022039428C43376680 @default.
• W2022039428 hasConceptScore W2022039428C71924100 @default.
• W2022039428 hasConceptScore W2022039428C98274493 @default.
• W2022039428 hasIssue "4" @default.
• W2022039428 hasLocation W20220394281 @default.
• W2022039428 hasLocation W20220394282 @default.
• W2022039428 hasLocation W20220394283 @default.
• W2022039428 hasLocation W20220394284 @default.
• W2022039428 hasLocation W20220394285 @default.
• W2022039428 hasLocation W20220394286 @default.
• W2022039428 hasOpenAccess W2022039428 @default.
• W2022039428 hasPrimaryLocation W20220394281 @default.
• W2022039428 hasRelatedWork W2355715737 @default.
• W2022039428 hasRelatedWork W2371458148 @default.
• W2022039428 hasRelatedWork W2375099669 @default.
• W2022039428 hasRelatedWork W2382438097 @default.
• W2022039428 hasRelatedWork W2386562888 @default.
• W2022039428 hasRelatedWork W2387343806 @default.
• W2022039428 hasRelatedWork W2393158999 @default.
• W2022039428 hasRelatedWork W2792706204 @default.
• W2022039428 hasRelatedWork W2998928564 @default.
• W2022039428 hasRelatedWork W4385059733 @default.
• W2022039428 hasVolume "67" @default.
• W2022039428 isParatext "false" @default.
• W2022039428 isRetracted "false" @default.
• W2022039428 magId "2022039428" @default.

• next