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- W2022040353 startingPage "1374" @default.
- W2022040353 abstract "In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca2+ signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species — which in turn modulate components of the Ca2+ signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion by plasma membrane Ca2+ pumps. Mitochondria can directly influence the calcium concentration in the cytosol of the cell by importing Ca2+ via the mitochondrial Ca2+ uniporter or transporting Ca2+ from the interior of the organelle into the cytosol by means of Na+/Ca2+ or H+/Ca2+ exchangers. Considerable progress in understanding the relationship between Ca2+ signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches." @default.
- W2022040353 created "2016-06-24" @default.
- W2022040353 creator A5017204235 @default.
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- W2022040353 creator A5065549009 @default.
- W2022040353 creator A5070648403 @default.
- W2022040353 creator A5072338475 @default.
- W2022040353 date "2009-11-01" @default.
- W2022040353 modified "2023-10-14" @default.
- W2022040353 title "Modulation of calcium signalling by mitochondria" @default.
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