FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022040497> ?p ?o ?g. }

• W2022040497 endingPage "4426" @default.
• W2022040497 startingPage "4417" @default.
• W2022040497 abstract "Success of chemotherapy is generally impaired by multidrug resistance, intrinsic resistance, or acquired resistance to functionally and structurally irrelevant drugs. Multidrug resistance emerges via distinct mechanisms: increased drug export, decreased drug internalization, dysfunctional apoptotic machinery, increased DNA damage repair, altered cell cycle regulation, and increased drug detoxification. Several reports demonstrated that multidrug resistance is a multifaceted problem such that multidrug resistance correlates with increased aggressiveness and metastatic potential. Here, we tested the involvement of protein kinase D2, a serine/threonine kinase that was previously implicated in proliferation, drug resistance, and motility in doxorubicin-resistant MCF7 (MCF7/DOX) cell line, which served as an in vitro model for drug resistance and invasiveness. We showed that basal level activity of protein kinase D2 (PKD2) was higher in MCF7/DOX cells than parental MCF7 cells. To elucidate the roles of PKD2 MCF7/DOX, PKD2 expression was reduced via small interfering RNA (siRNA)-mediated knockdown. Results showed that acquired resistance of MCF7/DOX to doxorubicin was not affected by PKD2 silencing, while motility of MCF7/DOX cells was reduced. The results implied that PKD2 silencing might inhibit migration of MCF7/DOX cells without affecting chemoresistance significantly." @default.
• W2022040497 created "2016-06-24" @default.
• W2022040497 creator A5064630705 @default.
• W2022040497 creator A5071755295 @default.
• W2022040497 date "2015-01-21" @default.
• W2022040497 modified "2023-09-23" @default.
• W2022040497 title "Protein kinase D2 silencing reduced motility of doxorubicin-resistant MCF7 cells" @default.
• W2022040497 cites W1553345136 @default.
• W2022040497 cites W1767659940 @default.
• W2022040497 cites W1841018361 @default.
• W2022040497 cites W1964847767 @default.
• W2022040497 cites W1972148801 @default.
• W2022040497 cites W1973071352 @default.
• W2022040497 cites W1982542571 @default.
• W2022040497 cites W1990079197 @default.
• W2022040497 cites W1994930469 @default.
• W2022040497 cites W1997916504 @default.
• W2022040497 cites W1998166198 @default.
• W2022040497 cites W2000271974 @default.
• W2022040497 cites W2013786989 @default.
• W2022040497 cites W2025452853 @default.
• W2022040497 cites W2031982181 @default.
• W2022040497 cites W2032204792 @default.
• W2022040497 cites W2047172303 @default.
• W2022040497 cites W2065629669 @default.
• W2022040497 cites W2066962839 @default.
• W2022040497 cites W2068482010 @default.
• W2022040497 cites W2072731290 @default.
• W2022040497 cites W2080434084 @default.
• W2022040497 cites W2081939461 @default.
• W2022040497 cites W2083953028 @default.
• W2022040497 cites W2087186743 @default.
• W2022040497 cites W2088415033 @default.
• W2022040497 cites W2090883234 @default.
• W2022040497 cites W2091312661 @default.
• W2022040497 cites W2092288031 @default.
• W2022040497 cites W2099499970 @default.
• W2022040497 cites W2116992704 @default.
• W2022040497 cites W2120205106 @default.
• W2022040497 cites W2136615032 @default.
• W2022040497 cites W2139287985 @default.
• W2022040497 cites W2146565973 @default.
• W2022040497 cites W2155200468 @default.
• W2022040497 cites W2157090463 @default.
• W2022040497 cites W2157783453 @default.
• W2022040497 cites W2162063324 @default.
• W2022040497 cites W2172155705 @default.
• W2022040497 cites W2187638624 @default.
• W2022040497 cites W22089090 @default.
• W2022040497 cites W2331229900 @default.
• W2022040497 cites W2399475545 @default.
• W2022040497 cites W4294413394 @default.
• W2022040497 doi "https://doi.org/10.1007/s13277-015-3081-3" @default.
• W2022040497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25874490" @default.
• W2022040497 hasPublicationYear "2015" @default.
• W2022040497 type Work @default.
• W2022040497 sameAs 2022040497 @default.
• W2022040497 citedByCount "11" @default.
• W2022040497 countsByYear W20220404972015 @default.
• W2022040497 countsByYear W20220404972016 @default.
• W2022040497 countsByYear W20220404972017 @default.
• W2022040497 countsByYear W20220404972019 @default.
• W2022040497 countsByYear W20220404972021 @default.
• W2022040497 countsByYear W20220404972022 @default.
• W2022040497 countsByYear W20220404972023 @default.
• W2022040497 crossrefType "journal-article" @default.
• W2022040497 hasAuthorship W2022040497A5064630705 @default.
• W2022040497 hasAuthorship W2022040497A5071755295 @default.
• W2022040497 hasConcept C104317684 @default.
• W2022040497 hasConcept C114851261 @default.
• W2022040497 hasConcept C119056186 @default.
• W2022040497 hasConcept C133936738 @default.
• W2022040497 hasConcept C173396325 @default.
• W2022040497 hasConcept C184235292 @default.
• W2022040497 hasConcept C190283241 @default.
• W2022040497 hasConcept C22615655 @default.
• W2022040497 hasConcept C2776694085 @default.
• W2022040497 hasConcept C2781303535 @default.
• W2022040497 hasConcept C502942594 @default.
• W2022040497 hasConcept C54009773 @default.
• W2022040497 hasConcept C54355233 @default.
• W2022040497 hasConcept C55493867 @default.
• W2022040497 hasConcept C58207958 @default.
• W2022040497 hasConcept C81885089 @default.
• W2022040497 hasConcept C86803240 @default.
• W2022040497 hasConcept C95444343 @default.
• W2022040497 hasConcept C97029542 @default.
• W2022040497 hasConcept C98274493 @default.
• W2022040497 hasConceptScore W2022040497C104317684 @default.
• W2022040497 hasConceptScore W2022040497C114851261 @default.
• W2022040497 hasConceptScore W2022040497C119056186 @default.
• W2022040497 hasConceptScore W2022040497C133936738 @default.
• W2022040497 hasConceptScore W2022040497C173396325 @default.
• W2022040497 hasConceptScore W2022040497C184235292 @default.
• W2022040497 hasConceptScore W2022040497C190283241 @default.
• W2022040497 hasConceptScore W2022040497C22615655 @default.
• W2022040497 hasConceptScore W2022040497C2776694085 @default.
• W2022040497 hasConceptScore W2022040497C2781303535 @default.

• next