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- W2022041737 endingPage "3121" @default.
- W2022041737 startingPage "3109" @default.
- W2022041737 abstract "Neurons with long projections are particularly liable to damage, which is reflected by a large group of hereditary neurodegenerative disorders that primarily affect these neurons. In the group of hereditary spastic paraplegias motor axons of the central nervous system degenerate, while distal pure motor neuropathies, Charcot-Marie-Tooth disorders and the group of hereditary sensory and autonomic neuropathies are characterized by degeneration of peripheral nerve fibres. Because the underlying pathologies share many parallels, the disorders are also referred to as axonopathies. A large number of genes has been associated with axonopathies and one of the emerging subgroups encodes membrane-shaping proteins with a central reticulon homology domain. Association of these proteins with lipid bilayers induces positive membrane curvature and influences the architecture of cellular organelles. Membrane-shaping proteins closely cooperate and directly interact with each other, but their structural features and localization to distinct subdomains of organelles suggests mutually exclusive roles. In some individuals a mutation in a shaping protein can result in upper motor neuron dysfunction, whereas in other patients it can lead to a degeneration of peripheral neurons. This suggests that membrane-shaping disorders might be considered as a continuous disease-spectrum of the axon." @default.
- W2022041737 created "2016-06-24" @default.
- W2022041737 creator A5009733924 @default.
- W2022041737 creator A5019536489 @default.
- W2022041737 date "2014-10-03" @default.
- W2022041737 modified "2023-10-13" @default.
- W2022041737 title "Membrane-shaping disorders: a common pathway in axon degeneration" @default.
- W2022041737 cites W1498629854 @default.
- W2022041737 cites W1506466708 @default.
- W2022041737 cites W1527737064 @default.
- W2022041737 cites W1941694581 @default.
- W2022041737 cites W1963573377 @default.
- W2022041737 cites W1966469057 @default.
- W2022041737 cites W1966962383 @default.
- W2022041737 cites W1968641405 @default.
- W2022041737 cites W1969203571 @default.
- W2022041737 cites W1970576768 @default.
- W2022041737 cites W1971275608 @default.
- W2022041737 cites W1972516264 @default.
- W2022041737 cites W1975075811 @default.
- W2022041737 cites W1975229775 @default.
- W2022041737 cites W1975935177 @default.
- W2022041737 cites W1976481511 @default.
- W2022041737 cites W1977960722 @default.
- W2022041737 cites W1978335715 @default.
- W2022041737 cites W1980730766 @default.
- W2022041737 cites W1980798766 @default.
- W2022041737 cites W1980900150 @default.
- W2022041737 cites W1984592684 @default.
- W2022041737 cites W1984651084 @default.
- W2022041737 cites W1988715808 @default.
- W2022041737 cites W2001362301 @default.
- W2022041737 cites W2004361183 @default.
- W2022041737 cites W2005513457 @default.
- W2022041737 cites W2007483105 @default.
- W2022041737 cites W2009098062 @default.
- W2022041737 cites W2015536770 @default.
- W2022041737 cites W2016859659 @default.
- W2022041737 cites W2019221181 @default.
- W2022041737 cites W2022025771 @default.
- W2022041737 cites W2024136850 @default.
- W2022041737 cites W2024537765 @default.
- W2022041737 cites W2025282224 @default.
- W2022041737 cites W2028073492 @default.
- W2022041737 cites W2029152767 @default.
- W2022041737 cites W2029237259 @default.
- W2022041737 cites W2030536974 @default.
- W2022041737 cites W2031364515 @default.
- W2022041737 cites W2032187471 @default.
- W2022041737 cites W2032362466 @default.
- W2022041737 cites W2034920745 @default.
- W2022041737 cites W2036766555 @default.
- W2022041737 cites W2038353996 @default.
- W2022041737 cites W2039612093 @default.
- W2022041737 cites W2042787144 @default.
- W2022041737 cites W2043714441 @default.
- W2022041737 cites W2047457777 @default.
- W2022041737 cites W2051687582 @default.
- W2022041737 cites W2052622892 @default.
- W2022041737 cites W2054051215 @default.
- W2022041737 cites W2056124210 @default.
- W2022041737 cites W2063006404 @default.
- W2022041737 cites W2063362637 @default.
- W2022041737 cites W2066015352 @default.
- W2022041737 cites W2068684706 @default.
- W2022041737 cites W2072084931 @default.
- W2022041737 cites W2074829213 @default.
- W2022041737 cites W2077390149 @default.
- W2022041737 cites W2077506140 @default.
- W2022041737 cites W2080179299 @default.
- W2022041737 cites W2084454676 @default.
- W2022041737 cites W2084701991 @default.
- W2022041737 cites W2085412209 @default.
- W2022041737 cites W2089198803 @default.
- W2022041737 cites W2090830396 @default.
- W2022041737 cites W2092310066 @default.
- W2022041737 cites W2094241924 @default.
- W2022041737 cites W2095578584 @default.
- W2022041737 cites W2097330469 @default.
- W2022041737 cites W2100997165 @default.
- W2022041737 cites W2103497223 @default.
- W2022041737 cites W2105729094 @default.
- W2022041737 cites W2109221324 @default.
- W2022041737 cites W2110810002 @default.
- W2022041737 cites W2113694337 @default.
- W2022041737 cites W2113977012 @default.
- W2022041737 cites W2116373233 @default.
- W2022041737 cites W2117053415 @default.
- W2022041737 cites W2117112155 @default.
- W2022041737 cites W2118296419 @default.
- W2022041737 cites W2119804506 @default.
- W2022041737 cites W2121014428 @default.
- W2022041737 cites W2133434856 @default.
- W2022041737 cites W2133515955 @default.
- W2022041737 cites W2134390983 @default.
- W2022041737 cites W2136338518 @default.
- W2022041737 cites W2137258759 @default.
- W2022041737 cites W2139683636 @default.