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- W2022042005 abstract "To investigate whether some aspects of patient or tumor characteristics influence the timing of local recurrence in breast cancer treated conservatively. A retrospective analysis was conducted on patients treated with conservative breast surgery followed by radiotherapy for breast carcinoma, and who developed local recurrence. Out of 2037 cases treated in our Institute, 59 local recurrences were observed within 36 months after treatment, called early local recurrence (ELR), and 87 local recurrences occurred after 60 months, called late local recurrence (LLR). Patient and tumor characteristics were analyzed in the 2 groups and compared. In patients with ELR, the mean age was 53, versus 54 in patients with LLR (ns). Likewise, the menopausal status was evenly distributed in the 2 groups. Primary tumors greater than 20 mm were more frequently found in patients with ELR: 35% vs. 19% in patients with LLR (p = 0.03). Grade 3 tumors were more encountered in patients with ELR: 35% vs. 8% in patients with LLR (p < 0.0001). Tumor ploidy was evenly distributed within the 2 groups. Patients with ELR had tumors with negative estrogen receptors more frequently than patients with LLR: 42% vs. 19% (p = 0.006), and negative progesterone receptors more frequently than patients with LLR: 54% vs. 22% (p = 0.0003). There was no statistically significant difference in the axillary lymph node (LN) status between patients with ELR and those with LLR: respectively 37% and 27% of positive LN (p = 0.18). The specific mortality was higher in patients with ELR: 63% vs. 24% for patients with LLR (p < 0.0001). Unfavorable tumor characteristics as big size, high grade, lack of hormone receptors, but not lymph node status were associated with ELR. The first 3 factors are often linked to tumor cell kinetics. These findings suggest that patients with such aggressive tumor characteristics who do not recur early will have a lower risk of LLR than patients with more favorable factors" @default.
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- W2022042005 date "2004-09-01" @default.
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- W2022042005 title "Early versus late local recurrences after conservative treatment of breast carcinoma. Are there differences in primary tumor characteristics" @default.
- W2022042005 doi "https://doi.org/10.1016/j.ijrobp.2004.07.066" @default.
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