FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022042292> ?p ?o ?g. }

• W2022042292 abstract "It has been shown that the MAO (monoamine oxidase)-B inhibitor deprenyl (DPR, selegiline) protects some cell types against oxidative stress. By decreasing H(2)O(2) production, MAO-A inhibitors could also reduce oxidative stress. This study reports the effect of the MAO-A inhibitors, pirlindole (PIR), dehydropirlindole (DHP), brofaromine (BRO) and moclobemide (MCL) on primary-cultured brain cells exposed to iron-mediated toxicity. A comparison with trolox (TRO), a hydrosoluble vitamin-E analogue that protects against such an induced stress, was performed. Rat hippocampal or cortical cultured cells were exposed either to 2 microM FeSO(4) alone or in the presence of PIR, DHP, BRO, DPR, MCL or TRO. Cell survival (lactate-dehydrogenase measurements, 16 h incubation), intracellular peroxide production (DCF-fluorescence, 1 h incubation), lipoperoxidation (TBARS-fluorescence, 6 h incubation) and mitochondrial function (MTT-test, 16 h incubation) were assessed. PIR, DHP and TRO significantly protected cultures (P<0.05) against Fe(2+)-induced toxicity in a concentration-dependent manner. The EC(50s) of these compounds were 6, 12 and 19 microM, respectively, in hippocampal cells. For cortical cell cultures incubated in the presence of iron and PIR or DHP, EC(50s) were 5 and 6 microM respectively. All Hill coefficients were close to unity. BRO, MCL and DPR were not protective in any type of culture. The IC(50s) for the inhibition of MAO-A were 2, 2 and 0.2 microM for PIR, DHP and BRO, respectively. PIR, DHP and TRO, but not DPR, induced a significant decrease in both intracellular peroxide production and lipoperoxidation. They also improved mitochondrial function. These experiments show that PIR and DHP can protect hippocampal and cortical neurons against oxidative stress at pharmacologically relevant concentrations. This protective effect seems unrelated to inhibition of MAO-A, but possibly involves free radical scavenging." @default.
• W2022042292 created "2016-06-24" @default.
• W2022042292 creator A5013668810 @default.
• W2022042292 creator A5059195873 @default.
• W2022042292 creator A5066772183 @default.
• W2022042292 creator A5067308851 @default.
• W2022042292 creator A5069132792 @default.
• W2022042292 date "2002-02-01" @default.
• W2022042292 modified "2023-09-28" @default.
• W2022042292 title "Pirlindole and dehydropirlindole protect rat cultured neuronal cells against oxidative stress-induced cell death through a mechanism unrelated to MAO-A inhibition" @default.
• W2022042292 cites W116026932 @default.
• W2022042292 cites W1507242444 @default.
• W2022042292 cites W1969280474 @default.
• W2022042292 cites W1975327214 @default.
• W2022042292 cites W1988691497 @default.
• W2022042292 cites W1990465549 @default.
• W2022042292 cites W2011437730 @default.
• W2022042292 cites W2013602632 @default.
• W2022042292 cites W2016336099 @default.
• W2022042292 cites W2022722834 @default.
• W2022042292 cites W2024707753 @default.
• W2022042292 cites W2024943443 @default.
• W2022042292 cites W2041993603 @default.
• W2022042292 cites W2063789588 @default.
• W2022042292 cites W2070089048 @default.
• W2022042292 cites W2072704848 @default.
• W2022042292 cites W2074132787 @default.
• W2022042292 cites W2075460133 @default.
• W2022042292 cites W2076433667 @default.
• W2022042292 cites W2080664227 @default.
• W2022042292 cites W2085868003 @default.
• W2022042292 cites W2094540217 @default.
• W2022042292 cites W2114918609 @default.
• W2022042292 cites W2119126576 @default.
• W2022042292 cites W2129902275 @default.
• W2022042292 cites W2138315398 @default.
• W2022042292 cites W2142456895 @default.
• W2022042292 cites W2142710389 @default.
• W2022042292 cites W2155356085 @default.
• W2022042292 cites W2175835252 @default.
• W2022042292 cites W2275421964 @default.
• W2022042292 cites W2289224145 @default.
• W2022042292 cites W2301404923 @default.
• W2022042292 cites W2326200998 @default.
• W2022042292 cites W2414843204 @default.
• W2022042292 cites W2415293558 @default.
• W2022042292 doi "https://doi.org/10.1038/sj.bjp.0704519" @default.
• W2022042292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1573183" @default.
• W2022042292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11834619" @default.
• W2022042292 hasPublicationYear "2002" @default.
• W2022042292 type Work @default.
• W2022042292 sameAs 2022042292 @default.
• W2022042292 citedByCount "11" @default.
• W2022042292 countsByYear W20220422922013 @default.
• W2022042292 countsByYear W20220422922016 @default.
• W2022042292 countsByYear W20220422922022 @default.
• W2022042292 crossrefType "journal-article" @default.
• W2022042292 hasAuthorship W2022042292A5013668810 @default.
• W2022042292 hasAuthorship W2022042292A5059195873 @default.
• W2022042292 hasAuthorship W2022042292A5066772183 @default.
• W2022042292 hasAuthorship W2022042292A5067308851 @default.
• W2022042292 hasAuthorship W2022042292A5069132792 @default.
• W2022042292 hasBestOaLocation W20220422922 @default.
• W2022042292 hasConcept C153911025 @default.
• W2022042292 hasConcept C178790620 @default.
• W2022042292 hasConcept C181199279 @default.
• W2022042292 hasConcept C185592680 @default.
• W2022042292 hasConcept C202751555 @default.
• W2022042292 hasConcept C2776024655 @default.
• W2022042292 hasConcept C2776151105 @default.
• W2022042292 hasConcept C2776231299 @default.
• W2022042292 hasConcept C2777318727 @default.
• W2022042292 hasConcept C29730261 @default.
• W2022042292 hasConcept C2993539680 @default.
• W2022042292 hasConcept C53227056 @default.
• W2022042292 hasConcept C55493867 @default.
• W2022042292 hasConcept C79879829 @default.
• W2022042292 hasConcept C86803240 @default.
• W2022042292 hasConcept C98274493 @default.
• W2022042292 hasConceptScore W2022042292C153911025 @default.
• W2022042292 hasConceptScore W2022042292C178790620 @default.
• W2022042292 hasConceptScore W2022042292C181199279 @default.
• W2022042292 hasConceptScore W2022042292C185592680 @default.
• W2022042292 hasConceptScore W2022042292C202751555 @default.
• W2022042292 hasConceptScore W2022042292C2776024655 @default.
• W2022042292 hasConceptScore W2022042292C2776151105 @default.
• W2022042292 hasConceptScore W2022042292C2776231299 @default.
• W2022042292 hasConceptScore W2022042292C2777318727 @default.
• W2022042292 hasConceptScore W2022042292C29730261 @default.
• W2022042292 hasConceptScore W2022042292C2993539680 @default.
• W2022042292 hasConceptScore W2022042292C53227056 @default.
• W2022042292 hasConceptScore W2022042292C55493867 @default.
• W2022042292 hasConceptScore W2022042292C79879829 @default.
• W2022042292 hasConceptScore W2022042292C86803240 @default.
• W2022042292 hasConceptScore W2022042292C98274493 @default.
• W2022042292 hasLocation W20220422921 @default.
• W2022042292 hasLocation W20220422922 @default.
• W2022042292 hasLocation W20220422923 @default.
• W2022042292 hasLocation W20220422924 @default.
• W2022042292 hasOpenAccess W2022042292 @default.

• next