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- W2022042426 abstract "WENDEL Yarbrough and colleagues (University of North Carolina at Chapel Hill, NC, USA) have made advances towards the treatment of head and neck cancer. 3-D cell-culture models that imitate the real structure of head and neck epithelium were used as recipients of adenovirus-mediated gene delivery. Epithelial cells in a monolayer were easy to infect due to the presence of the human coxsackie and adenovirus receptor (hCAR). However, the group noted that expression of hCAR was most prevalent in undifferentiated dividing cells, particularly oropharyngeal tumor cells. This raises the prospect of adenoviral gene delivery to these tumor sites without affecting surrounding non-cancerous cells. Furthermore, such a system may prove useful in treating severe cellular dysplasia, a precancerous condition in which hCAR expression is maintained. Yarbrough commented, ‘theoretically, in people at high risk for cancer, adenoviral gene therapy would only infect the precancerous sites and leave the normal, well differentiated sites alone’. (AR)." @default.
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- W2022042426 date "2001-01-01" @default.
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- W2022042426 title "Gene therapy for the head and neck" @default.
- W2022042426 doi "https://doi.org/10.1016/s1471-4914(00)01894-3" @default.
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