Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022043453> ?p ?o ?g. }
- W2022043453 endingPage "3204" @default.
- W2022043453 startingPage "3196" @default.
- W2022043453 abstract "Spirochetes are well-known as causative agents of various chronic infectious diseases. Glycolipids of small-sized Treponema spirochetes have been shown to exhibit immunostimulating activities. In this study, we found that a glycoconjugate preparation obtained from Treponema medium (Tm-Gp), an intermediate-sized oral Treponema seen in subgingival plaque from patients with chronic periodontal diseases, diminished the LPS-induced activation of a human monocytic cell line, while TNF-alpha-induced activation was unaffected. NF-kappaB activation in Ba/F3 cells expressing murine Toll-like receptor (TLR) 4 and MD-2 was inhibited by Tm-Gp in a CD14/LPS-binding protein (LBP)-dependent manner when stimulated with LPS or its active center lipid A but not when stimulated with Taxol. Tm-Gp blocked the binding of LPS to immobilized CD14 and LBP and inhibited nitric oxide (NO) production by a murine Mphi cell line following stimulation with peptidoglycan and LPS in the presence of FBS, while NO production in response poly (I:C) RNA or CpG DNA remained unaffected. The inhibitory effects of Tm-Gp seem to be attributable to the lipophilic portion of the glycoconjugate. These results indicate that T. medium contains a glycoconjugate possessing an inhibitory effect on TLR-mediated cell activation through interaction with LBP and CD14." @default.
- W2022043453 created "2016-06-24" @default.
- W2022043453 creator A5028597074 @default.
- W2022043453 creator A5063503649 @default.
- W2022043453 creator A5086529614 @default.
- W2022043453 date "2003-11-01" @default.
- W2022043453 modified "2023-09-30" @default.
- W2022043453 title "Treponemal glycoconjugate inhibits Toll-like receptor ligand-induced cell activation by blocking LPS-binding protein and CD14 functions" @default.
- W2022043453 cites W1488995655 @default.
- W2022043453 cites W1501761310 @default.
- W2022043453 cites W1514540900 @default.
- W2022043453 cites W1523183151 @default.
- W2022043453 cites W1527612695 @default.
- W2022043453 cites W1542029261 @default.
- W2022043453 cites W1663724591 @default.
- W2022043453 cites W1673257055 @default.
- W2022043453 cites W1959569047 @default.
- W2022043453 cites W1964604460 @default.
- W2022043453 cites W1964794992 @default.
- W2022043453 cites W1974565437 @default.
- W2022043453 cites W1978926805 @default.
- W2022043453 cites W1981592920 @default.
- W2022043453 cites W2004773897 @default.
- W2022043453 cites W2008651707 @default.
- W2022043453 cites W2016862474 @default.
- W2022043453 cites W2022013606 @default.
- W2022043453 cites W2024803597 @default.
- W2022043453 cites W2029157767 @default.
- W2022043453 cites W2032514624 @default.
- W2022043453 cites W2034016916 @default.
- W2022043453 cites W2037490361 @default.
- W2022043453 cites W2047376205 @default.
- W2022043453 cites W2057809738 @default.
- W2022043453 cites W2058352235 @default.
- W2022043453 cites W2064626913 @default.
- W2022043453 cites W2073565085 @default.
- W2022043453 cites W2076361525 @default.
- W2022043453 cites W2078837287 @default.
- W2022043453 cites W2093419159 @default.
- W2022043453 cites W2095833996 @default.
- W2022043453 cites W2100876508 @default.
- W2022043453 cites W2112799653 @default.
- W2022043453 cites W2113828544 @default.
- W2022043453 cites W2120005533 @default.
- W2022043453 cites W2120227455 @default.
- W2022043453 cites W2122597944 @default.
- W2022043453 cites W2123706707 @default.
- W2022043453 cites W2129319296 @default.
- W2022043453 cites W2130840482 @default.
- W2022043453 cites W2132177571 @default.
- W2022043453 cites W2134726269 @default.
- W2022043453 cites W2138067578 @default.
- W2022043453 cites W2145803213 @default.
- W2022043453 cites W2146749940 @default.
- W2022043453 cites W2147221919 @default.
- W2022043453 cites W2147687946 @default.
- W2022043453 cites W2149999204 @default.
- W2022043453 cites W2151120686 @default.
- W2022043453 cites W2152168515 @default.
- W2022043453 cites W2160647188 @default.
- W2022043453 doi "https://doi.org/10.1002/eji.200324219" @default.
- W2022043453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14579288" @default.
- W2022043453 hasPublicationYear "2003" @default.
- W2022043453 type Work @default.
- W2022043453 sameAs 2022043453 @default.
- W2022043453 citedByCount "31" @default.
- W2022043453 countsByYear W20220434532012 @default.
- W2022043453 countsByYear W20220434532013 @default.
- W2022043453 countsByYear W20220434532014 @default.
- W2022043453 countsByYear W20220434532015 @default.
- W2022043453 countsByYear W20220434532016 @default.
- W2022043453 countsByYear W20220434532018 @default.
- W2022043453 countsByYear W20220434532019 @default.
- W2022043453 countsByYear W20220434532021 @default.
- W2022043453 countsByYear W20220434532023 @default.
- W2022043453 crossrefType "journal-article" @default.
- W2022043453 hasAuthorship W2022043453A5028597074 @default.
- W2022043453 hasAuthorship W2022043453A5063503649 @default.
- W2022043453 hasAuthorship W2022043453A5086529614 @default.
- W2022043453 hasBestOaLocation W20220434531 @default.
- W2022043453 hasConcept C104317684 @default.
- W2022043453 hasConcept C13426554 @default.
- W2022043453 hasConcept C136449434 @default.
- W2022043453 hasConcept C153911025 @default.
- W2022043453 hasConcept C170493617 @default.
- W2022043453 hasConcept C203014093 @default.
- W2022043453 hasConcept C2776634448 @default.
- W2022043453 hasConcept C2776709828 @default.
- W2022043453 hasConcept C2776983459 @default.
- W2022043453 hasConcept C2778513237 @default.
- W2022043453 hasConcept C2780187896 @default.
- W2022043453 hasConcept C3013748606 @default.
- W2022043453 hasConcept C54355233 @default.
- W2022043453 hasConcept C55493867 @default.
- W2022043453 hasConcept C81885089 @default.
- W2022043453 hasConcept C86803240 @default.
- W2022043453 hasConcept C89423630 @default.
- W2022043453 hasConceptScore W2022043453C104317684 @default.