FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022045327> ?p ?o ?g. }

• W2022045327 endingPage "510" @default.
• W2022045327 startingPage "499" @default.
• W2022045327 abstract "Glomerular parietal epithelial cells (PECs) are precursors to podocytes in mature glomeruli; however, as progenitors, the distinct intrinsic mechanisms that allow for repeated periods of cell-cycle arrest and re-entry of PECs after glomerulogenesis are unknown. Here, we show that the Src-suppressed protein kinase C substrate (SSeCKS), a multivalent scaffolding A kinase anchoring protein, sequesters cyclin D1 in the cytoplasm of quiescent PECs. SSeCKS expression is induced in embryonic PECs, but not in embryonic podocytes, starting at the S phase of glomerulogenesis, and is constitutively expressed postnatally by PECs, but not podocytes, in normal glomeruli. Cyclin D1 was immunoprecipitated with SSeCKS from capsulated glomeruli containing PECs, whereas decapsulated glomeruli without PECs lacked SSeCKS and cyclin D1. Cell-cell contact inhibition of proliferation in cultured PECs induced SSeCKS expression and binding of cyclin D1 by SSeCKS in the cytoplasm, whereas phosphorylation of SSeCKS by activated protein kinase C disrupted binding, resulting in nuclear translocation of cyclin D1. SSeCKS(-/-) mice showed hyperplasia of PECs in otherwise normal glomeruli and developed significantly worse proteinuric glomerular disease, marked by increased PEC proliferation and expression of nuclear cyclin D1, from nephrotoxic nephritis. These results suggest that SSeCKS controls the localization and activity of cyclin D1 in PECs and influences proliferative injury in the glomerulus." @default.
• W2022045327 created "2016-06-24" @default.
• W2022045327 creator A5007845859 @default.
• W2022045327 creator A5014518109 @default.
• W2022045327 creator A5021412093 @default.
• W2022045327 creator A5022177889 @default.
• W2022045327 creator A5027246219 @default.
• W2022045327 creator A5034232036 @default.
• W2022045327 creator A5046662102 @default.
• W2022045327 creator A5047698585 @default.
• W2022045327 creator A5050532491 @default.
• W2022045327 creator A5066665709 @default.
• W2022045327 creator A5069985048 @default.
• W2022045327 creator A5074507585 @default.
• W2022045327 date "2012-01-16" @default.
• W2022045327 modified "2023-10-17" @default.
• W2022045327 title "SSeCKS sequesters cyclin D1 in glomerular parietal epithelial cells and influences proliferative injury in the glomerulus" @default.
• W2022045327 cites W1969177158 @default.
• W2022045327 cites W1971898307 @default.
• W2022045327 cites W1987379081 @default.
• W2022045327 cites W1987496015 @default.
• W2022045327 cites W1987928007 @default.
• W2022045327 cites W1998740840 @default.
• W2022045327 cites W2002879179 @default.
• W2022045327 cites W2012370766 @default.
• W2022045327 cites W2021955237 @default.
• W2022045327 cites W2023208472 @default.
• W2022045327 cites W2043085269 @default.
• W2022045327 cites W2043804549 @default.
• W2022045327 cites W2050589760 @default.
• W2022045327 cites W2068429410 @default.
• W2022045327 cites W2072802709 @default.
• W2022045327 cites W2075974804 @default.
• W2022045327 cites W2077995946 @default.
• W2022045327 cites W2086357948 @default.
• W2022045327 cites W2090576076 @default.
• W2022045327 cites W2099517948 @default.
• W2022045327 cites W2127172867 @default.
• W2022045327 cites W2127373567 @default.
• W2022045327 cites W2134035270 @default.
• W2022045327 cites W2135099361 @default.
• W2022045327 cites W2135447662 @default.
• W2022045327 cites W2137061781 @default.
• W2022045327 cites W2140028599 @default.
• W2022045327 cites W2151787127 @default.
• W2022045327 cites W2163406006 @default.
• W2022045327 cites W2164633978 @default.
• W2022045327 cites W2171058117 @default.
• W2022045327 cites W2186108493 @default.
• W2022045327 cites W2395274642 @default.
• W2022045327 cites W320395961 @default.
• W2022045327 cites W4211123666 @default.
• W2022045327 cites W4247406457 @default.
• W2022045327 doi "https://doi.org/10.1038/labinvest.2011.199" @default.
• W2022045327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22249313" @default.
• W2022045327 hasPublicationYear "2012" @default.
• W2022045327 type Work @default.
• W2022045327 sameAs 2022045327 @default.
• W2022045327 citedByCount "31" @default.
• W2022045327 countsByYear W20220453272012 @default.
• W2022045327 countsByYear W20220453272013 @default.
• W2022045327 countsByYear W20220453272014 @default.
• W2022045327 countsByYear W20220453272015 @default.
• W2022045327 countsByYear W20220453272016 @default.
• W2022045327 countsByYear W20220453272017 @default.
• W2022045327 countsByYear W20220453272018 @default.
• W2022045327 countsByYear W20220453272019 @default.
• W2022045327 countsByYear W20220453272020 @default.
• W2022045327 countsByYear W20220453272021 @default.
• W2022045327 countsByYear W20220453272022 @default.
• W2022045327 countsByYear W20220453272023 @default.
• W2022045327 crossrefType "journal-article" @default.
• W2022045327 hasAuthorship W2022045327A5007845859 @default.
• W2022045327 hasAuthorship W2022045327A5014518109 @default.
• W2022045327 hasAuthorship W2022045327A5021412093 @default.
• W2022045327 hasAuthorship W2022045327A5022177889 @default.
• W2022045327 hasAuthorship W2022045327A5027246219 @default.
• W2022045327 hasAuthorship W2022045327A5034232036 @default.
• W2022045327 hasAuthorship W2022045327A5046662102 @default.
• W2022045327 hasAuthorship W2022045327A5047698585 @default.
• W2022045327 hasAuthorship W2022045327A5050532491 @default.
• W2022045327 hasAuthorship W2022045327A5066665709 @default.
• W2022045327 hasAuthorship W2022045327A5069985048 @default.
• W2022045327 hasAuthorship W2022045327A5074507585 @default.
• W2022045327 hasBestOaLocation W20220453271 @default.
• W2022045327 hasConcept C11882975 @default.
• W2022045327 hasConcept C120089663 @default.
• W2022045327 hasConcept C126322002 @default.
• W2022045327 hasConcept C134018914 @default.
• W2022045327 hasConcept C1491633281 @default.
• W2022045327 hasConcept C199835354 @default.
• W2022045327 hasConcept C29537977 @default.
• W2022045327 hasConcept C502942594 @default.
• W2022045327 hasConcept C55493867 @default.
• W2022045327 hasConcept C71924100 @default.
• W2022045327 hasConcept C86803240 @default.
• W2022045327 hasConcept C95444343 @default.
• W2022045327 hasConceptScore W2022045327C11882975 @default.

• next