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- W2022045360 abstract "The possible role of medial forebrain bundle (MFB) catecholaminergic fibers in the previously observed MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid negative feedback effects has been investigated. MFB catecholaminergic fibers were destroyed by bilateral MFB injections of 6-hydroxydopamine (6-OHDA) to adult male rats. The inhibitory effect of dexamethasone (10 micrograms, i.p., 4 h) upon the adrenocortical secretory response to ether stress, as estimated by serum corticosterone levels, was enhanced in the 6-OHDA-treated animals, as compared to vehicle-injected controls. This study suggests that MFB noradrenergic neurons are at least partially responsible for the MFB-mediated modulation of hypothalamic sensitivity to glucocorticoid hormones." @default.
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- W2022045360 date "1983-02-01" @default.
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- W2022045360 title "Role of medial forebrain bundle catecholaminergic fibers in the modulation of glucocorticoid negative feedback effects" @default.
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- W2022045360 doi "https://doi.org/10.1016/0006-8993(83)90684-4" @default.
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