Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022046401> ?p ?o ?g. }
- W2022046401 endingPage "3411" @default.
- W2022046401 startingPage "3406" @default.
- W2022046401 abstract "An important goal of vaccination is to achieve long-term survival of functional memory T cells. Using a MHC-compatible adoptive transfer system, we show here that a short, 3-day IL-4 but not IL-2 or IL-12 exposure during in vitro T cell receptor stimulation of naive CD8(+) T cells induced long-lasting in vivo memory. Such long-term memory CD8(+) T cells expressed antigen-specific cytotoxicity and the potential for IFN-gamma and IL-4 production. Our results support the concept that functional T cell longevity can be regulated by cytokines during initial antigen encounter and provide a rational foundation for vaccine development. They also may have implications in formulating optimal therapeutic regimens of ex vivo expanded autologous cancer- and HIV-specific CD8(+) T cells. In addition, the availability of large numbers of memory CD8(+) T cells generated through our high-efficiency system should facilitate progress in the molecular dissection of CD8(+) T cell memory development." @default.
- W2022046401 created "2016-06-24" @default.
- W2022046401 creator A5005468953 @default.
- W2022046401 creator A5010282233 @default.
- W2022046401 creator A5019389546 @default.
- W2022046401 creator A5039462162 @default.
- W2022046401 creator A5080242521 @default.
- W2022046401 date "2000-03-21" @default.
- W2022046401 modified "2023-10-01" @default.
- W2022046401 title "Potent induction of long-term CD8+ T cell memory by short-term IL-4 exposure during T cell receptor stimulation" @default.
- W2022046401 cites W1490404690 @default.
- W2022046401 cites W1506908530 @default.
- W2022046401 cites W1511926246 @default.
- W2022046401 cites W1516330538 @default.
- W2022046401 cites W1555235592 @default.
- W2022046401 cites W1556055983 @default.
- W2022046401 cites W1558126419 @default.
- W2022046401 cites W1568059997 @default.
- W2022046401 cites W1569140775 @default.
- W2022046401 cites W1596782482 @default.
- W2022046401 cites W1600662889 @default.
- W2022046401 cites W1602344543 @default.
- W2022046401 cites W1612135387 @default.
- W2022046401 cites W1817153273 @default.
- W2022046401 cites W1845629018 @default.
- W2022046401 cites W1962631004 @default.
- W2022046401 cites W1967884480 @default.
- W2022046401 cites W1970735079 @default.
- W2022046401 cites W1974906492 @default.
- W2022046401 cites W1975601462 @default.
- W2022046401 cites W1978408586 @default.
- W2022046401 cites W1979514172 @default.
- W2022046401 cites W1996350333 @default.
- W2022046401 cites W2001035036 @default.
- W2022046401 cites W2006027051 @default.
- W2022046401 cites W2008366157 @default.
- W2022046401 cites W2008750159 @default.
- W2022046401 cites W2025465431 @default.
- W2022046401 cites W2026606109 @default.
- W2022046401 cites W2029154862 @default.
- W2022046401 cites W2029836713 @default.
- W2022046401 cites W2030747697 @default.
- W2022046401 cites W2037692840 @default.
- W2022046401 cites W2042825771 @default.
- W2022046401 cites W2055087053 @default.
- W2022046401 cites W2061140050 @default.
- W2022046401 cites W2070437307 @default.
- W2022046401 cites W2072903392 @default.
- W2022046401 cites W2085583663 @default.
- W2022046401 cites W2086847331 @default.
- W2022046401 cites W2090896399 @default.
- W2022046401 cites W2091217693 @default.
- W2022046401 cites W2091691801 @default.
- W2022046401 cites W2126302947 @default.
- W2022046401 cites W2132544581 @default.
- W2022046401 cites W2132976350 @default.
- W2022046401 cites W2133567701 @default.
- W2022046401 cites W2135041525 @default.
- W2022046401 cites W2138773604 @default.
- W2022046401 cites W2144373451 @default.
- W2022046401 cites W2155262309 @default.
- W2022046401 cites W2160985360 @default.
- W2022046401 cites W2171009645 @default.
- W2022046401 doi "https://doi.org/10.1073/pnas.060026497" @default.
- W2022046401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/16252" @default.
- W2022046401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10725381" @default.
- W2022046401 hasPublicationYear "2000" @default.
- W2022046401 type Work @default.
- W2022046401 sameAs 2022046401 @default.
- W2022046401 citedByCount "44" @default.
- W2022046401 countsByYear W20220464012012 @default.
- W2022046401 countsByYear W20220464012013 @default.
- W2022046401 countsByYear W20220464012014 @default.
- W2022046401 countsByYear W20220464012015 @default.
- W2022046401 countsByYear W20220464012017 @default.
- W2022046401 countsByYear W20220464012018 @default.
- W2022046401 countsByYear W20220464012020 @default.
- W2022046401 countsByYear W20220464012021 @default.
- W2022046401 crossrefType "journal-article" @default.
- W2022046401 hasAuthorship W2022046401A5005468953 @default.
- W2022046401 hasAuthorship W2022046401A5010282233 @default.
- W2022046401 hasAuthorship W2022046401A5019389546 @default.
- W2022046401 hasAuthorship W2022046401A5039462162 @default.
- W2022046401 hasAuthorship W2022046401A5080242521 @default.
- W2022046401 hasBestOaLocation W20220464012 @default.
- W2022046401 hasConcept C121332964 @default.
- W2022046401 hasConcept C167672396 @default.
- W2022046401 hasConcept C169760540 @default.
- W2022046401 hasConcept C170493617 @default.
- W2022046401 hasConcept C185592680 @default.
- W2022046401 hasConcept C203014093 @default.
- W2022046401 hasConcept C24998067 @default.
- W2022046401 hasConcept C2776090121 @default.
- W2022046401 hasConcept C55493867 @default.
- W2022046401 hasConcept C61797465 @default.
- W2022046401 hasConcept C62520636 @default.
- W2022046401 hasConcept C86803240 @default.
- W2022046401 hasConcept C8891405 @default.