FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022048384> ?p ?o ?g. }

• W2022048384 abstract "Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Infections of the respiratory tract are a hallmark in CF. The host immune responses in CF are not adequate to eradicate pathogens, such as P. aeruginosa. Dendritic cells (DC) are crucial in initiation and regulation of immune responses. Changes in DC function could contribute to abnormal immune responses on multiple levels. The role of DC in CF lung disease remains unknown.This study investigated the expression of CFTR gene in bone marrow-derived DC. We compared the differentiation and maturation profile of DC from CF and wild type (WT) mice. We analyzed the gene expression levels in DC from naive CF and WT mice or following P. aeruginosa infection.CFTR is expressed in DC with lower level compared to lung tissue. DC from CF mice showed a delayed in the early phase of differentiation. Gene expression analysis in DC generated from naive CF and WT mice revealed decreased expression of Caveolin-1 (Cav1), a membrane lipid raft protein, in the CF DC compared to WT DC. Consistently, protein and activity levels of the sterol regulatory element binding protein (SREBP), a negative regulator of Cav1 expression, were increased in CF DC. Following exposure to P. aeruginosa, expression of 3beta-hydroxysterol-Delta7 reductase (Dhcr7) and stearoyl-CoA desaturase 2 (Scd2), two enzymes involved in the lipid metabolism that are also regulated by SREBP, was less decreased in the CF DC compared to WT DC.These results suggest that CFTR dysfunction in DC affects factors involved in membrane structure and lipid-metabolism, which may contribute to the abnormal inflammatory and immune response characteristic of CF." @default.
• W2022048384 created "2016-06-24" @default.
• W2022048384 creator A5031349718 @default.
• W2022048384 creator A5033366410 @default.
• W2022048384 creator A5050729392 @default.
• W2022048384 creator A5060190581 @default.
• W2022048384 creator A5064433832 @default.
• W2022048384 creator A5084238530 @default.
• W2022048384 date "2009-04-03" @default.
• W2022048384 modified "2023-10-16" @default.
• W2022048384 title "Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells" @default.
• W2022048384 cites W1519234019 @default.
• W2022048384 cites W1590926802 @default.
• W2022048384 cites W1786185665 @default.
• W2022048384 cites W1875555978 @default.
• W2022048384 cites W1908899750 @default.
• W2022048384 cites W1919118030 @default.
• W2022048384 cites W1964626438 @default.
• W2022048384 cites W1968784553 @default.
• W2022048384 cites W1969731177 @default.
• W2022048384 cites W1977054730 @default.
• W2022048384 cites W1977956480 @default.
• W2022048384 cites W1978986568 @default.
• W2022048384 cites W1984026469 @default.
• W2022048384 cites W1984350355 @default.
• W2022048384 cites W1985931909 @default.
• W2022048384 cites W1987325291 @default.
• W2022048384 cites W1994622879 @default.
• W2022048384 cites W1998195903 @default.
• W2022048384 cites W2004844038 @default.
• W2022048384 cites W2013306854 @default.
• W2022048384 cites W2015376902 @default.
• W2022048384 cites W2016532191 @default.
• W2022048384 cites W2021447304 @default.
• W2022048384 cites W2022497999 @default.
• W2022048384 cites W2023339317 @default.
• W2022048384 cites W2026911184 @default.
• W2022048384 cites W2033496470 @default.
• W2022048384 cites W2036433325 @default.
• W2022048384 cites W2039599894 @default.
• W2022048384 cites W2039867846 @default.
• W2022048384 cites W2052613838 @default.
• W2022048384 cites W2055857822 @default.
• W2022048384 cites W2058161348 @default.
• W2022048384 cites W2060753180 @default.
• W2022048384 cites W2063684531 @default.
• W2022048384 cites W2081287274 @default.
• W2022048384 cites W2084460940 @default.
• W2022048384 cites W2085861288 @default.
• W2022048384 cites W2087222747 @default.
• W2022048384 cites W2088905535 @default.
• W2022048384 cites W2091561409 @default.
• W2022048384 cites W2096316556 @default.
• W2022048384 cites W2100340328 @default.
• W2022048384 cites W2109038233 @default.
• W2022048384 cites W2112987667 @default.
• W2022048384 cites W2114994684 @default.
• W2022048384 cites W2125901361 @default.
• W2022048384 cites W2126057936 @default.
• W2022048384 cites W2128963767 @default.
• W2022048384 cites W2133931920 @default.
• W2022048384 cites W2138486337 @default.
• W2022048384 cites W2145757273 @default.
• W2022048384 cites W2148433370 @default.
• W2022048384 cites W2154804960 @default.
• W2022048384 cites W2164448670 @default.
• W2022048384 cites W2169545551 @default.
• W2022048384 cites W2170240282 @default.
• W2022048384 cites W4211074500 @default.
• W2022048384 cites W4252021281 @default.
• W2022048384 doi "https://doi.org/10.1186/1465-9921-10-26" @default.
• W2022048384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2683168" @default.
• W2022048384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19344509" @default.
• W2022048384 hasPublicationYear "2009" @default.
• W2022048384 type Work @default.
• W2022048384 sameAs 2022048384 @default.
• W2022048384 citedByCount "30" @default.
• W2022048384 countsByYear W20220483842012 @default.
• W2022048384 countsByYear W20220483842013 @default.
• W2022048384 countsByYear W20220483842014 @default.
• W2022048384 countsByYear W20220483842015 @default.
• W2022048384 countsByYear W20220483842016 @default.
• W2022048384 countsByYear W20220483842017 @default.
• W2022048384 countsByYear W20220483842019 @default.
• W2022048384 countsByYear W20220483842020 @default.
• W2022048384 countsByYear W20220483842021 @default.
• W2022048384 countsByYear W20220483842022 @default.
• W2022048384 crossrefType "journal-article" @default.
• W2022048384 hasAuthorship W2022048384A5031349718 @default.
• W2022048384 hasAuthorship W2022048384A5033366410 @default.
• W2022048384 hasAuthorship W2022048384A5050729392 @default.
• W2022048384 hasAuthorship W2022048384A5060190581 @default.
• W2022048384 hasAuthorship W2022048384A5064433832 @default.
• W2022048384 hasAuthorship W2022048384A5084238530 @default.
• W2022048384 hasBestOaLocation W20220483841 @default.
• W2022048384 hasConcept C104317684 @default.
• W2022048384 hasConcept C150194340 @default.
• W2022048384 hasConcept C153911025 @default.
• W2022048384 hasConcept C170493617 @default.
• W2022048384 hasConcept C203014093 @default.

• next