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- W2022050896 abstract "Histone H1 is an essential chromatin component. Metazoans usually contain multiple stage-specific H1s. In particular, specific variants replace somatic H1s during early embryogenesis. In this regard, Drosophila was an exception because a single dH1 was identified that, starting at cellularization, is detected throughout development in somatic cells. Here, we identify the embryonic H1 of Drosophila, dBigH1. dBigH1 is abundant before cellularization occurs, when somatic dH1 is absent and the zygotic genome is inactive. Upon cellularization, when the zygotic genome is progressively activated, dH1 replaces dBigH1 in the soma, but not in the primordial germ cells (PGCs) that have delayed zygotic genome activation (ZGA). In addition, a loss-of-function mutant shows premature ZGA in both the soma and PGCs. Mutant embryos die at cellularization, showing increased levels of active RNApol II and zygotic transcripts, along with DNA damage and mitotic defects. These results show an essential function of dBigH1 in ZGA regulation." @default.
- W2022050896 created "2016-06-24" @default.
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- W2022050896 date "2013-09-01" @default.
- W2022050896 modified "2023-10-12" @default.
- W2022050896 title "The Embryonic Linker Histone H1 Variant of Drosophila, dBigH1, Regulates Zygotic Genome Activation" @default.
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- W2022050896 cites W1587679755 @default.
- W2022050896 cites W1967896329 @default.
- W2022050896 cites W1968685605 @default.
- W2022050896 cites W1969218808 @default.
- W2022050896 cites W1970764247 @default.
- W2022050896 cites W1974302507 @default.
- W2022050896 cites W1975267925 @default.
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- W2022050896 cites W2007473333 @default.
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- W2022050896 doi "https://doi.org/10.1016/j.devcel.2013.08.011" @default.
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