FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022051483> ?p ?o ?g. }

• W2022051483 endingPage "4724" @default.
• W2022051483 startingPage "4716" @default.
• W2022051483 abstract "In the germinative zone of the adult rodent brain, neural progenitors migrate into niches delimited by astrocyte processes and differentiate into neuronal precursors. In the present study, we report a modulating role for the scaffolding protein IQGAP1 in neural progenitor migration. We have identified IQGAP1 as a new marker of amplifying neural progenitor and neuronal precursor cells of the subventricular zone (SVZ) and the rostral migratory stream (RMS) in the adult mouse brain. To determine functions for IQGAP1 in neural progenitors, we compared the properties of neural progenitor cells from wild-type and Iqgap1 -null mutant mice in vivo and in vitro . The in vivo studies reveal a delay in the transition of de novo neural progenitors into neuronal precursor cells in Iqgap1 -null mice. In vitro , we demonstrated that IQGAP1 acts as a downstream effector in the vascular endothelial growth factor (VEGF)-dependent migratory response of neural progenitors that also impacts on their neuronal differentiation. The Rho-family GTPases cdc42/Rac1 and Lis1 are major partners of IQGAP1 in this migratory process. Finally, astrocytes of the neurogenic SVZ and RMS are shown to express VEGF. We propose that VEGF synthesized by astrocytes could be involved in the guidance of neural progenitors to neurogenic niches and that IQGAP1 is an effector of the VEGF-dependent migratory signal." @default.
• W2022051483 created "2016-06-24" @default.
• W2022051483 creator A5000876359 @default.
• W2022051483 creator A5008046544 @default.
• W2022051483 creator A5034399082 @default.
• W2022051483 creator A5057052331 @default.
• W2022051483 creator A5059069293 @default.
• W2022051483 creator A5072008847 @default.
• W2022051483 creator A5082312852 @default.
• W2022051483 date "2007-04-25" @default.
• W2022051483 modified "2023-10-05" @default.
• W2022051483 title "IQGAP1 Regulates Adult Neural Progenitors<i>In Vivo</i>and Vascular Endothelial Growth Factor-Triggered Neural Progenitor Migration<i>In Vitro</i>" @default.
• W2022051483 cites W1487852103 @default.
• W2022051483 cites W1840746752 @default.
• W2022051483 cites W1859730138 @default.
• W2022051483 cites W1965681567 @default.
• W2022051483 cites W1977055303 @default.
• W2022051483 cites W1979566928 @default.
• W2022051483 cites W1981829804 @default.
• W2022051483 cites W1995854663 @default.
• W2022051483 cites W2003982930 @default.
• W2022051483 cites W2007242343 @default.
• W2022051483 cites W2008287057 @default.
• W2022051483 cites W2009175120 @default.
• W2022051483 cites W2014386715 @default.
• W2022051483 cites W2020277172 @default.
• W2022051483 cites W2035555613 @default.
• W2022051483 cites W2043584138 @default.
• W2022051483 cites W2047568883 @default.
• W2022051483 cites W2048525391 @default.
• W2022051483 cites W2051021067 @default.
• W2022051483 cites W2053068006 @default.
• W2022051483 cites W2073652272 @default.
• W2022051483 cites W2077735056 @default.
• W2022051483 cites W2084995170 @default.
• W2022051483 cites W2085761963 @default.
• W2022051483 cites W2092502717 @default.
• W2022051483 cites W2100173413 @default.
• W2022051483 cites W2110437484 @default.
• W2022051483 cites W2117523148 @default.
• W2022051483 cites W2135279715 @default.
• W2022051483 cites W2144383844 @default.
• W2022051483 cites W2145116035 @default.
• W2022051483 cites W2151028126 @default.
• W2022051483 cites W2166949826 @default.
• W2022051483 cites W2167961416 @default.
• W2022051483 doi "https://doi.org/10.1523/jneurosci.0830-07.2007" @default.
• W2022051483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6672986" @default.
• W2022051483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17460084" @default.
• W2022051483 hasPublicationYear "2007" @default.
• W2022051483 type Work @default.
• W2022051483 sameAs 2022051483 @default.
• W2022051483 citedByCount "36" @default.
• W2022051483 countsByYear W20220514832012 @default.
• W2022051483 countsByYear W20220514832013 @default.
• W2022051483 countsByYear W20220514832014 @default.
• W2022051483 countsByYear W20220514832015 @default.
• W2022051483 countsByYear W20220514832017 @default.
• W2022051483 countsByYear W20220514832018 @default.
• W2022051483 countsByYear W20220514832019 @default.
• W2022051483 countsByYear W20220514832020 @default.
• W2022051483 countsByYear W20220514832023 @default.
• W2022051483 crossrefType "journal-article" @default.
• W2022051483 hasAuthorship W2022051483A5000876359 @default.
• W2022051483 hasAuthorship W2022051483A5008046544 @default.
• W2022051483 hasAuthorship W2022051483A5034399082 @default.
• W2022051483 hasAuthorship W2022051483A5057052331 @default.
• W2022051483 hasAuthorship W2022051483A5059069293 @default.
• W2022051483 hasAuthorship W2022051483A5072008847 @default.
• W2022051483 hasAuthorship W2022051483A5082312852 @default.
• W2022051483 hasBestOaLocation W20220514831 @default.
• W2022051483 hasConcept C104317684 @default.
• W2022051483 hasConcept C124964019 @default.
• W2022051483 hasConcept C136834591 @default.
• W2022051483 hasConcept C15729860 @default.
• W2022051483 hasConcept C169760540 @default.
• W2022051483 hasConcept C201750760 @default.
• W2022051483 hasConcept C202751555 @default.
• W2022051483 hasConcept C2777222312 @default.
• W2022051483 hasConcept C2777542381 @default.
• W2022051483 hasConcept C2779560292 @default.
• W2022051483 hasConcept C28328180 @default.
• W2022051483 hasConcept C461258 @default.
• W2022051483 hasConcept C4746552 @default.
• W2022051483 hasConcept C529278444 @default.
• W2022051483 hasConcept C53645450 @default.
• W2022051483 hasConcept C54355233 @default.
• W2022051483 hasConcept C62478195 @default.
• W2022051483 hasConcept C86803240 @default.
• W2022051483 hasConcept C95444343 @default.
• W2022051483 hasConceptScore W2022051483C104317684 @default.
• W2022051483 hasConceptScore W2022051483C124964019 @default.
• W2022051483 hasConceptScore W2022051483C136834591 @default.
• W2022051483 hasConceptScore W2022051483C15729860 @default.
• W2022051483 hasConceptScore W2022051483C169760540 @default.
• W2022051483 hasConceptScore W2022051483C201750760 @default.
• W2022051483 hasConceptScore W2022051483C202751555 @default.
• W2022051483 hasConceptScore W2022051483C2777222312 @default.

• next