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- W2022052051 abstract "• Leptin receptors are found within hypothalamic and brainstem neuronal populations. • Leptin in the brainstem acts as an indirect signal that modifies the direct controls of food intake. • Manipulation of central leptin receptors has identified substrates important in energy balance. The adiposity hormone leptin has been implicated in the regulation of behavioral and metabolic controls of body weight. Leptin receptors are found in multiple peripheral and central tissues, particularly within hypothalamic and brainstem neuronal populations. Central leptinergic signaling acts as an indirect control to modulate the feeding inhibitory potency of the direct controls of meal size. Mouse models of neuronal leptin loss and gain of function have helped to identify and characterize how central leptin contributes to the central control of food intake." @default.
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- W2022052051 date "2013-12-01" @default.
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- W2022052051 title "Roles for central leptin receptors in the control of meal size" @default.
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- W2022052051 doi "https://doi.org/10.1016/j.appet.2013.04.017" @default.
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