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• W2022052456 abstract "Ovarian reserve can be diminished following treatment for breast cancer. This study evaluated biochemical and biophysical parameters of ovarian reserve in these patients. Biochemical and biophysical tests of ovarian reserve were performed simultaneously in young (age 22–42 years), regularly menstruating women with breast cancer (n=22) and age-matched controls (n=24). All tests were performed before (baseline) and after transient ovarian stimulation in the early follicular phase. Patients were recruited both before and after completion of chemotherapy, with some patients being followed up prospectively. Serum samples were analysed for follicle-stimulating hormone (FSH), luteinising hormone (LH), oestradiol (E2), inhibins A and B, and antimullerian hormone (AMH). Biophysical (ultrasound) tests included ovarian volume, antral follicle count (AFC), ovarian stromal blood flow and uterine dimensions. Significant differences were revealed (when compared with the controls) for basal FSH (11.32±1.48 vs 6.62±0.42 mIU ml−1, P<0.001), basal AMH (0.95±0.34 vs 7.89±1.62 ng ml−1, P<0.001) and basal inhibin B (19.24±4.56 vs 83.61±13.45 pg ml−1, P<0.001). Following transient ovarian stimulation, there were significant differences in the increment change (Δ) for inhibin B (3.02±2.3 vs 96.82±16.38 pg ml−1, P<0.001) and E2 (107.8±23.95 vs 283.2±40.34 pg ml−1, P<0.01). AFC was the only biophysical parameter that was significantly different between patients and the controls (7.80±0.85 vs 16.77±1.11, P<0.001). Basal and stimulated biochemical (serum AMH, FSH, inhibin B and E2) and biophysical (AFC) tests may be potential markers of ovarian reserve in young women with breast cancer." @default.
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• W2022052456 date "2007-05-29" @default.
• W2022052456 modified "2023-10-16" @default.
• W2022052456 title "Predictors of ovarian reserve in young women with breast cancer" @default.
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• W2022052456 doi "https://doi.org/10.1038/sj.bjc.6603814" @default.
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