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- W2022053588 abstract "Fifty-three patients with first episodes and 60 patients with prior culture proven recurrent genital herpes were enrolled in a single centre, double-blind, placebo-controlled trial of 5% acyclovir in an aqueous cream base versus matching placebo. For first episodes treated with topical acyclovir the median duration of pain (4 vs. 8 days, P < 0.05), time to healing of all lesions (8 vs. 14 days, P < 0.001), duration of viral shedding (4 vs. 11 days, P = 0.001) and duration of new lesion formation (0 vs. 2.5 days, P < 0.001) were reduced compared with placebo recipients. In patients with recurrent episodes who completed the study topical acyclovir significantly reduced the median duration of all symptoms (3 vs. 6 days, P < 0.001), the time to healing of all lesions (4 vs. 6 days, P < 0.01), and the formation of new lesions (5 vs. 29%, P < 0.01) compared with the controls. Greater clinical benefits were demonstrated in females than in males, particularly for first episodes, but the number of males was small. Topical acyclovir cream is well tolerated and an effective treatment for first and recurrent episodes of genital herpes." @default.
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- W2022053588 date "1983-12-01" @default.
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- W2022053588 title "Efficacy of topical acyclovir cream in first and recurrent episodes of genital herpes" @default.
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- W2022053588 doi "https://doi.org/10.1016/0166-3542(83)90037-2" @default.
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