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- W2022054438 abstract "It is well known that biological membranes are susceptible to lipid peroxidation [ 11. Effects of per- oxidative damage on energy-linked functions and membrane enzymes of mitochondria were reported [2]. In the presence of pro-oxidants isolated mito- chondria swell and lyse after incubation in salt media and concomitantly lipid peroxides were accumulated [3]. Inhibitory actions of antioxidants on these pro- cesses were noted [4]. Probably one of the earliest events following lipid peroxidation is an alteration in ionic permeability of the mitochondrial membrane. It was shown recently that during oscillations of ion fluxes in mitochondrial suspensions, periodic increases and decreases of membrane permeability and passive ion fluxes occur [5]. The obvious advan- tages of such a reversible system of mitochondrial ion transport prompted us to study the influence of different antioxidants on the process of mitochondrial oscillatory ion fluxes. The main effect of all anti- oxidants studied was the inhibition of ion efflux during the oscillatory cycle without significant influences on either active transport or oxidative phosphorylation 2." @default.
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- W2022054438 date "1979-11-01" @default.
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- W2022054438 title "Inhibition of cation efflux by antioxidants during oscillatory ion transport in mitochondria" @default.
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- W2022054438 doi "https://doi.org/10.1016/0014-5793(79)80484-6" @default.
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