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- W2022054761 abstract "Our aim was t o assess the efficacy of an early psychosocial intervention for outpatients with mild Alzheimer's disease (AD) and their caregivers to delay nursing home placement. Totally 240 patient-caregiver dyads living in three municipalities in Finland were recruited to a prospective, randomized, and controlled rehabilitation ALSOVA study. Inclusion criteria for the patients were ≥65 years of age, very mild (clinical dementia rating, CDR 0.5) or mild (CDR 1) AD, informed consent and a family caregiver. Eligible patient-caregiver pairs were randomized to one of two groups. The intervention group received usual care and additional intensive psychosocial courses during the first 2 years after diagnosis. The other group received only the usual care. A primary outcome was the effect of the intervention on risk of institutionalization during the three years of follow up. In addition, following secondary outcome measures were sociodemographic factors, cognitive function, behavioral symptoms, activities in daily living, specific health conditions, medication, health and social care resource utilization, generic quality of life, and Alzheimer's disease specific quality of life were collected at each interview. Difference in risk of institutionalization between the randomized groups was evaluated by a hazard ratio from a Cox regression model. The research ethics committee of the University of Kuopio and Kuopio University Hospital gave approval to carry out the study. After 36 months of follow-up totally 18% of patients with AD were dead and around 33% of them were institutionalized. Cox proportional hazard model's log-rank test indicated statistically non-significant (p=0.39) difference between groups in risk of institutionalization. Intensive psychosocial intervention for patients with mild Alzheimer's disease and their caregivers did not manage to delay time to institutionalization. Even if, the ALSOVA study did not manage to show statistically significant difference between the study groups, it provides the valuable dataset for studying of long-term disease progression and its consequences for patients with Alzheimer's disease and their caregivers." @default.
- W2022054761 created "2016-06-24" @default.
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- W2022054761 date "2013-07-01" @default.
- W2022054761 modified "2023-10-16" @default.
- W2022054761 title "O3-05-03: Early psychosocial intervention did not delay institutionalization in patients with Alzheimer's disease: ALSOVA study reports" @default.
- W2022054761 doi "https://doi.org/10.1016/j.jalz.2013.04.262" @default.
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