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- W2022055559 abstract "Abstract Infection with Sindbis virus had little effect on the incorporation of P 32 into the nucleotide pool or the RNA of chick fibroblast cells. Phospholipid synthesis, however, was soon slowed to less than half the rate in uninfected cells. When cells were infected shortly after transfer to a medium containing P 32 O 4 , the specific activities of nucleotides in the viral RNA approached that of the phosphate in the medium. The viral RNA thus appears to be synthesized de novo . Under identical labeling conditions the specific activities of the viral phosphatides were much lower than that of the phosphate in the medium. When cells were labeled with P 32 and then incubated for 30 hours in unlabeled medium before infection, each individual phosphatide in the infected cell and in the purified virus had a nearly identical specific activity. It is concluded that the viral phospholipid is largely derived from preexisting cellular phosphatides." @default.
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- W2022055559 date "1963-07-01" @default.
- W2022055559 modified "2023-09-27" @default.
- W2022055559 title "The source of the ribonucleic acid and phospholipid of Sindbis virus" @default.
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- W2022055559 doi "https://doi.org/10.1016/0042-6822(63)90093-x" @default.
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