FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022058532> ?p ?o ?g. }

• W2022058532 endingPage "25" @default.
• W2022058532 startingPage "19" @default.
• W2022058532 abstract "Vpr and Vpx are primate lentivirus proteins that manipulate the cellular CRL4 ubiquitin ligase complex. While Vpr is common to all primate lentiviruses, Vpx is only encoded by HIV-2 and a limited range of SIVs. Although Vpr and Vpx share a high degree of homology they are known to induce markedly different effects in host cell biology through the recruitment of different substrates to CRL4. Here we explore the interaction of HIV-1 Vpr and SIVmac Vpx with the CRL4 substrate receptor DCAF1. Through mutational analysis of DCAF1 we demonstrate that although Vpr and Vpx share a highly similar DCAF1-binding motif, they interact with a different set of residues in DCAF1. In addition, we show that Vpx recruits SAMHD1 through a protein-protein interface that includes interactions of SAMHD1 with both Vpx and DCAF1, as was first suggested in crystallography data by (Schwefel, D., Groom, H.C.T., Boucherit, V.C., Christodoulou, E., Walker, P.A., Stoye, J.P., Bishop, K.N., Taylor, I.A., 2014. Structural basis of lentiviral subversion of a cellular protein degradation pathway., Nature, 505, 234-238)." @default.
• W2022058532 created "2016-06-24" @default.
• W2022058532 creator A5042773644 @default.
• W2022058532 creator A5053594741 @default.
• W2022058532 creator A5071328207 @default.
• W2022058532 creator A5074854290 @default.
• W2022058532 creator A5091801673 @default.
• W2022058532 creator A5091816254 @default.
• W2022058532 date "2015-02-01" @default.
• W2022058532 modified "2023-10-17" @default.
• W2022058532 title "Understanding the molecular manipulation of DCAF1 by the lentiviral accessory proteins Vpr and Vpx" @default.
• W2022058532 cites W1577222354 @default.
• W2022058532 cites W1585763437 @default.
• W2022058532 cites W1962784494 @default.
• W2022058532 cites W1964567249 @default.
• W2022058532 cites W1965565827 @default.
• W2022058532 cites W1969211936 @default.
• W2022058532 cites W1975282459 @default.
• W2022058532 cites W1982434350 @default.
• W2022058532 cites W1985585046 @default.
• W2022058532 cites W1986384364 @default.
• W2022058532 cites W1991069890 @default.
• W2022058532 cites W1991103421 @default.
• W2022058532 cites W1999932815 @default.
• W2022058532 cites W2009745550 @default.
• W2022058532 cites W2010577903 @default.
• W2022058532 cites W2011524434 @default.
• W2022058532 cites W2012514245 @default.
• W2022058532 cites W2026218505 @default.
• W2022058532 cites W2029930485 @default.
• W2022058532 cites W2031875199 @default.
• W2022058532 cites W2032735361 @default.
• W2022058532 cites W2042486230 @default.
• W2022058532 cites W2051043258 @default.
• W2022058532 cites W2060309579 @default.
• W2022058532 cites W2062400835 @default.
• W2022058532 cites W2066829584 @default.
• W2022058532 cites W2068349374 @default.
• W2022058532 cites W2068784898 @default.
• W2022058532 cites W2069554621 @default.
• W2022058532 cites W2069841786 @default.
• W2022058532 cites W2080159885 @default.
• W2022058532 cites W2087392654 @default.
• W2022058532 cites W2092114045 @default.
• W2022058532 cites W2092229871 @default.
• W2022058532 cites W2098862724 @default.
• W2022058532 cites W2115657133 @default.
• W2022058532 cites W2117313364 @default.
• W2022058532 cites W2129784359 @default.
• W2022058532 cites W2130200446 @default.
• W2022058532 cites W2131736388 @default.
• W2022058532 cites W2137015675 @default.
• W2022058532 cites W2140226886 @default.
• W2022058532 cites W2143625239 @default.
• W2022058532 cites W2146501674 @default.
• W2022058532 cites W2149138273 @default.
• W2022058532 cites W2149678150 @default.
• W2022058532 cites W2153044822 @default.
• W2022058532 cites W2159006922 @default.
• W2022058532 cites W2159113944 @default.
• W2022058532 cites W2164223256 @default.
• W2022058532 cites W2170324534 @default.
• W2022058532 doi "https://doi.org/10.1016/j.virol.2014.11.024" @default.
• W2022058532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4323848" @default.
• W2022058532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25499532" @default.
• W2022058532 hasPublicationYear "2015" @default.
• W2022058532 type Work @default.
• W2022058532 sameAs 2022058532 @default.
• W2022058532 citedByCount "8" @default.
• W2022058532 countsByYear W20220585322015 @default.
• W2022058532 countsByYear W20220585322016 @default.
• W2022058532 countsByYear W20220585322017 @default.
• W2022058532 countsByYear W20220585322018 @default.
• W2022058532 countsByYear W20220585322019 @default.
• W2022058532 countsByYear W20220585322020 @default.
• W2022058532 countsByYear W20220585322023 @default.
• W2022058532 crossrefType "journal-article" @default.
• W2022058532 hasAuthorship W2022058532A5042773644 @default.
• W2022058532 hasAuthorship W2022058532A5053594741 @default.
• W2022058532 hasAuthorship W2022058532A5071328207 @default.
• W2022058532 hasAuthorship W2022058532A5074854290 @default.
• W2022058532 hasAuthorship W2022058532A5091801673 @default.
• W2022058532 hasAuthorship W2022058532A5091816254 @default.
• W2022058532 hasBestOaLocation W20220585321 @default.
• W2022058532 hasConcept C104317684 @default.
• W2022058532 hasConcept C11804247 @default.
• W2022058532 hasConcept C134459356 @default.
• W2022058532 hasConcept C156719811 @default.
• W2022058532 hasConcept C159047783 @default.
• W2022058532 hasConcept C25602115 @default.
• W2022058532 hasConcept C2776315342 @default.
• W2022058532 hasConcept C2777995582 @default.
• W2022058532 hasConcept C3013748606 @default.
• W2022058532 hasConcept C45005369 @default.
• W2022058532 hasConcept C54355233 @default.
• W2022058532 hasConcept C67705224 @default.
• W2022058532 hasConcept C86803240 @default.
• W2022058532 hasConcept C95444343 @default.

• next