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• W2022059441 abstract "Cytokines are increasingly recognized as important components of the cellular immune responses to intracellular pathogens. In this study, we analyzed the production of TGF-β, IL-10 and IFN-γ by PBMC of unexposed naïve subjects and LCL patients after stimulation with live Leishmania guyanensis (L.g.). We demonstrated that IFN-γ is produced in controls and LCL patients, IL-10 only in LCL patients and TGF-β only in naïve subjects. Furthermore, in naive subjects, neutralization of TGF-β induced IL-10 production. IL-10 produced in naïve subjects when TGF-β is neutralized or in LCL patients did not modify the IFN-γ production but inhibit reactive nitrogen species production. Analysis of the phenotype of IL-10 producing cells in naive subjects when TGF-β is neutralized clearly showed that they are memory CD45RA− CD8+ T cells. In LCL patients, IL-10 producing cells are both CD45RA− CD4 and CD8+ T cells. The role of these IL-10 producing CD8+ T cells in the development of the diseases should be carefully evaluated." @default.
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• W2022059441 date "2007-07-01" @default.
• W2022059441 modified "2023-09-23" @default.
• W2022059441 title "IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis" @default.
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• W2022059441 doi "https://doi.org/10.1016/j.micinf.2007.04.009" @default.
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